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Yang, Joon Mo
Medical Device and System Lab.
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High-speed label-free functional photoacoustic microscopy of mouse brain in action

Author(s)
Yao, JunjieWang, LidaiYang, Joon-MoMaslov, Konstantin I.Wong, Terence T. W.Li, LeiHuang, Chih-HsienZou, JunWang, Lihong V.
Issued Date
2015-05
DOI
10.1038/nmeth.3336
URI
https://scholarworks.unist.ac.kr/handle/201301/24057
Fulltext
https://www.nature.com/articles/nmeth.3336
Citation
NATURE METHODS, v.12, no.5, pp.407 - 410
Abstract
We present fast functional photoacoustic microscopy (PAMAM) for three-dimensional high-resolution, high-speed imaging of the mouse brain, complementary to other imaging modalities. We implemented a single-wavelength pulse-width-based method with a one-dimensional imaging rate of 100 kHz to image blood oxygenation with capillary-level resolution. We applied PAMAM to image the vascular morphology, blood oxygenation, blood flow and oxygen metabolism in both resting and stimulated states in the mouse brain
Publisher
NATURE PUBLISHING GROUP
ISSN
1548-7091
Keyword
IN-VIVOHEMODYNAMIC-CHANGESOXYGENTISSUECORTEX

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