File Download

There are no files associated with this item.

  • Find it @ UNIST can give you direct access to the published full text of this article. (UNISTARs only)
Related Researcher

박종화

Bhak, Jong
KOrean GenomIcs Center
Read More

Views & Downloads

Detailed Information

Cited time in webofscience Cited time in scopus
Metadata Downloads

Genomic structure of the native inhabitants of Peninsular Malaysia and North Borneo suggests complex human population history in Southeast Asia

Author(s)
Yew, Chee-WeiLu, DongshengDeng, LianWong, Lai-PingOng, Rick Twee-HeeLu, YanWang, XiaojiYunus, YushimahAghakhanian, FarhangMokhtar, Siti ShuhadaHoque, Mohammad ZahirulVoo, Christopher Lok-YungRahman, Thuhairah AbdulBhak, JongPhipps, Maude E.Xu, ShuhuaTeo, Yik-YingKumar, Subbiah VijayHoh, Boon-Peng
Issued Date
2018-02
DOI
10.1007/s00439-018-1869-0
URI
https://scholarworks.unist.ac.kr/handle/201301/23848
Fulltext
https://link.springer.com/article/10.1007%2Fs00439-018-1869-0
Citation
HUMAN GENETICS, v.137, no.2, pp.161 - 173
Abstract
Southeast Asia (SEA) is enriched with a complex history of peopling. Malaysia, which is located at the crossroads of SEA, has been recognized as one of the hubs for early human migration. To unravel the genomic complexity of the native inhabitants of Malaysia, we sequenced 12 samples from 3 indigenous populations from Peninsular Malaysia and 4 native populations from North Borneo to a high coverage of 28-37x. We showed that the Negritos from Peninsular Malaysia shared a common ancestor with the East Asians, but exhibited some level of gene flow from South Asia, while the North Borneo populations exhibited closer genetic affinity towards East Asians than the Malays. The analysis of time of divergence suggested that ancestors of Negrito were the earliest settlers in the Malay Peninsula, whom first separated from the Papuans similar to 50-33 thousand years ago (kya), followed by East Asian (similar to 40-15 kya), while the divergence time frame between North Borneo and East Asia populations predates the Austronesian expansion period implies a possible pre-Neolithic colonization. Substantial Neanderthal ancestry was confirmed in our genomes, as was observed in other East Asians. However, no significant difference was observed, in terms of the proportion of Denisovan gene flow into these native inhabitants from Malaysia. Judging from the similar amount of introgression in the Southeast Asians and East Asians, our findings suggest that the Denisovan gene flow may have occurred before the divergence of these populations and that the shared similarities are likely an ancestral component.
Publisher
SPRINGER
ISSN
0340-6717
Keyword
MITOCHONDRIAL-DNAGENETIC HISTORYINDIGENOUS POPULATIONSNEANDERTHAL ANCESTRYEVOLUTIONARY HISTORYPOSITIVE SELECTIONHUMAN DISPERSALSADMIXTUREADAPTATIONMIGRATION

qrcode

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.