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- Park, Tae-Eun
- Micro Tissue Engineering & Nanomedicine Lab.
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Gene therapy for bone tissue engineering
- Author(s)
- Kim, Young-Dong, Pofali, Prasad, Park, Tae-Eun, Singh, Bijay, Cho, Kihyun, Maharjan, Sushila, Dandekar, Prajakta, Jain, Ratnesh, Choi, Yun-Jaie, Arote, Rohidas, Cho, Chong-Su
- Issued Date
- 2016-04
- Citation
- TISSUE ENGINEERING AND REGENERATIVE MEDICINE, v.13, no.2, pp.111 - 125
- Abstract
- Gene therapy holds a great promise and has been extensively investigated to improve bone formation and regeneration therapies in bone tissue engineering. A variety of osteogenic genes can be delivered by combining different vectors (viral or non-viral), scaffolds and delivery methodologies. Ex vivo & in vivo gene enhanced tissue engineering approaches have led to successful osteogenic differentiation and bone formation. In this article, we review recent advances of gene therapy-based bone tissue engineering discussing strengths and weaknesses of various strategies as well as general overview of gene therapy.
- Publisher
- KOREAN TISSUE ENGINEERING REGENERATIVE MEDICINE SOC
- ISSN
- 1738-2696
- Keyword (Author)
- Gene therapy, Viral vector, Non-viral vector, Bone tissue engineering, Bone morphogenetic protein
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