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DC Field | Value | Language |
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dc.citation.endPage | 1490 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1479 | - |
dc.citation.title | DIABETES | - |
dc.citation.volume | 66 | - |
dc.contributor.author | Park, Jiyoung | - |
dc.contributor.author | Kim, Min | - |
dc.contributor.author | Sun, Kai | - |
dc.contributor.author | An, Yu Aaron | - |
dc.contributor.author | Gu, Xue | - |
dc.contributor.author | Scherer, Philipp | - |
dc.date.accessioned | 2023-12-21T22:12:33Z | - |
dc.date.available | 2023-12-21T22:12:33Z | - |
dc.date.created | 2017-03-15 | - |
dc.date.issued | 2017-06 | - |
dc.description.abstract | Adipocyte-derived VEGF-A plays a crucial role in angiogenesis and contributes to adipocyte function and systemic metabolism, such as insulin resistance, chronic inflammation and beigeing of subcutaneous adipose tissue. Utilizing a doxycycline (Dox)-inducible adipocyte-specific VEGF-A overexpressing mouse model, we investigated the dynamics of local VEGF-A effects on tissue beiging of adipose tissue transplants. VEGF-A overexpression in adipocytes triggers angiogenesis. We also observe a rapid appearance of beige fat cells in subcutaneous white adipose tissue (sWATs) within as early as 2 days post induction of VEGF-A. In contrast to conventional cold-induced beiging, VEGF-A - induced beiging is independent of IL-4. We subjected metabolically healthy VEGF-A overexpressing adipose tissue to autologous transplantation. Transfer of subcutaneous adipose tissues taken from VEGF-A overexpressing mice into diet-induced obese mice resulted in systemic metabolic benefits, associated with improved survival of adipocytes and a concomitant reduced inflammatory response. These effects of VEGF-A are tissue autonomous, inducing WAT beigeing and angiogenesis within the transplanted tissue. Our findings indicate that manipulation of adipocyte functions with a bona fide angiogenic factor, such as VEGF-A, significantly improves the survival and volume retention of fat grafts and can convey metabolically favorable properties on the recipient on the basis of beiging. | - |
dc.identifier.bibliographicCitation | DIABETES, v.66, no.6, pp.1479 - 1490 | - |
dc.identifier.doi | 10.2337/db16-1081 | - |
dc.identifier.issn | 0012-1797 | - |
dc.identifier.scopusid | 2-s2.0-85019592196 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/21986 | - |
dc.identifier.url | http://diabetes.diabetesjournals.org/content/66/6/1479 | - |
dc.identifier.wosid | 000401700400008 | - |
dc.language | 영어 | - |
dc.publisher | AMER DIABETES ASSOC | - |
dc.title | VEGF-A Expressing Adipose Tissue Shows Rapid Beiging, Enhanced Survival After Transplantation and Confers IL4-Independent Metabolic Improvements | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject.keywordPlus | INSULIN SENSITIVITY | - |
dc.subject.keywordPlus | FAT GRAFTS | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | ADIPOCYTES | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | ADIPONECTIN | - |
dc.subject.keywordPlus | DYSFUNCTION | - |
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