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Thermoplastic nanofluidic devices for biomedical applications

Author(s)
Weerakoon-Ratnayake, Kumuditha M.O'Neil, Colleen E.Uba, Franklin I.Soper, Steven A.
Issued Date
2017-02
DOI
10.1039/c6lc01173j
URI
https://scholarworks.unist.ac.kr/handle/201301/21823
Fulltext
http://pubs.rsc.org/en/Content/ArticleLanding/2017/LC/C6LC01173J#!divAbstract
Citation
LAB ON A CHIP, v.17, no.3, pp.362 - 381
Abstract
Microfluidics is now moving into a developmental stage where basic discoveries are being transitioned into the commercial sector so that these discoveries can affect, for example, healthcare. Thus, high production rate microfabrication technologies, such as thermal embossing and/or injection molding, are being used to produce low-cost consumables appropriate for commercial applications. Based on recent reports, it is clear that nanofluidics offers some attractive process capabilities that may provide unique venues for biomolecular analyses that cannot be realized at the microscale. Thus, it would be attractive to consider early in the developmental cycle of nanofluidics production pipelines that can generate devices possessing sub150 nm dimensions in a high production mode and at low-cost to accommodate the commercialization of this exciting technology. Recently, functional sub-150 nm thermoplastic nanofluidic devices have been reported that can provide high process yield rates, which can enable commercial translation of nanofluidics. This review presents an overview of recent advancements in the fabrication, assembly, surface modification and the characterization of thermoplastic nanofluidic devices. Also, several examples in which nanoscale phenomena have been exploited for the analysis of biomolecules are highlighted. Lastly, some general conclusions and future outlooks are presented.
Publisher
ROYAL SOC CHEMISTRY
ISSN
1473-0197
Keyword
MOLECULAR-DYNAMICS SIMULATIONOXYGEN PLASMA TREATMENTSINGLE DNA NUCLEOTIDESSURFACE MODIFICATIONELECTROKINETIC TRANSPORTMICROFLUIDIC DEVICESPOLYMER NANOCHANNELSCONCENTRATION POLARIZATIONPHYSIOCHEMICAL PROPERTIESELECTROOSMOTIC FLOW

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