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DC Field | Value | Language |
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dc.citation.endPage | 258 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 249 | - |
dc.citation.title | CELL | - |
dc.citation.volume | 95 | - |
dc.contributor.author | Lau, Albert Y. | - |
dc.contributor.author | Scharer, Orlando D. | - |
dc.contributor.author | Samson, Leona | - |
dc.contributor.author | Verdine, Gregory L. | - |
dc.contributor.author | Ellenberger, Tom | - |
dc.date.accessioned | 2023-12-22T12:14:13Z | - |
dc.date.available | 2023-12-22T12:14:13Z | - |
dc.date.created | 2017-01-26 | - |
dc.date.issued | 1998-10 | - |
dc.description.abstract | DNA N-glycosylases are base excision-repair proteins that locate and cleave damaged bases from DNA as the first step in restoring the genetic blueprint. The human enzyme 3-methyladenine DNA glycosylase removes a diverse group of damaged bases from DNA, including cytotoxic and mutagenic alkylation adducts of purines. We report the crystal structure of human 3-methyladenine DNA glycosylase complexed to a mechanism-based pyrrolidine inhibitor. The enzyme has intercalated into the minor groove of DNA, causing the abasic pyrrolidine nucleotide to flip into the enzyme active site, where a bound water is poised for nucleophilic attack. The structure shows an elegant means of exposing a nucleotide for base excision as well as a network of residues that could catalyze the in-line displacement of a damaged base from the phosphodeoxyribose backbone. | - |
dc.identifier.bibliographicCitation | CELL, v.95, no.2, pp.249 - 258 | - |
dc.identifier.doi | 10.1016/S0092-8674(00)81755-9 | - |
dc.identifier.issn | 0092-8674 | - |
dc.identifier.scopusid | 2-s2.0-0032538337 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/21297 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0092867400817559 | - |
dc.identifier.wosid | 000076538300012 | - |
dc.language | 영어 | - |
dc.publisher | CELL PRESS | - |
dc.title | Crystal structure of a human alkylbase-DNA repair enzyme complexed to DNA: Mechanisms for nucleotide flipping and base excision | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
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