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DC Field | Value | Language |
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dc.citation.endPage | 1701 | - |
dc.citation.number | 5960 | - |
dc.citation.startPage | 1698 | - |
dc.citation.title | SCIENCE | - |
dc.citation.volume | 326 | - |
dc.contributor.author | Knipscheer, Puck | - |
dc.contributor.author | Raeschle, Markus | - |
dc.contributor.author | Smogorzewska, Agata | - |
dc.contributor.author | Enoiu, Milica | - |
dc.contributor.author | Ho, The Vinh | - |
dc.contributor.author | Schaerer, Orlando D. | - |
dc.contributor.author | Elledge, Stephen J. | - |
dc.contributor.author | Walter, Johannes C. | - |
dc.date.accessioned | 2023-12-22T07:36:48Z | - |
dc.date.available | 2023-12-22T07:36:48Z | - |
dc.date.created | 2017-01-26 | - |
dc.date.issued | 2009-12 | - |
dc.description.abstract | Fanconi anemia is a human cancer predisposition syndrome caused by mutations in 13 Fanc genes. The disorder is characterized by genomic instability and cellular hypersensitivity to chemicals that generate DNA interstrand cross-links (ICLs). A central event in the activation of the Fanconi anemia pathway is the mono-ubiquitylation of the FANCI-FANCD2 complex, but how this complex confers ICL resistance remains enigmatic. Using a cell-free system, we showed that FANCI-FANCD2 is required for replication-coupled ICL repair in S phase. Removal of FANCD2 from extracts inhibits both nucleolytic incisions near the ICL and translesion DNA synthesis past the lesion. Reversal of these defects requires ubiquitylated FANCI-FANCD2. Our results show that multiple steps of the essential S-phase ICL repair mechanism fail when the Fanconi anemia pathway is compromised | - |
dc.identifier.bibliographicCitation | SCIENCE, v.326, no.5960, pp.1698 - 1701 | - |
dc.identifier.doi | 10.1126/science.1182372 | - |
dc.identifier.issn | 0036-8075 | - |
dc.identifier.scopusid | 2-s2.0-72949123930 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/21265 | - |
dc.identifier.url | http://science.sciencemag.org/content/326/5960/1698 | - |
dc.identifier.wosid | 000272839000054 | - |
dc.language | 영어 | - |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | - |
dc.title | The Fanconi Anemia Pathway Promotes Replication-Dependent DNA Interstrand Cross-Link Repair | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
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