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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 329 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 321 | - |
dc.citation.title | CELL | - |
dc.citation.volume | 86 | - |
dc.contributor.author | Labahn, Jorg | - |
dc.contributor.author | Scharer, Orlando D. | - |
dc.contributor.author | Long, Alexander | - |
dc.contributor.author | EzazNikpay, Khosro | - |
dc.contributor.author | Verdine, Gregory L. | - |
dc.contributor.author | Ellenberger, Tom E. | - |
dc.date.accessioned | 2023-12-22T12:39:10Z | - |
dc.date.available | 2023-12-22T12:39:10Z | - |
dc.date.created | 2017-01-26 | - |
dc.date.issued | 1996-07 | - |
dc.description.abstract | Base-excision DNA repair proteins that target alkylation damage act on a variety of seemingly dissimilar adducts, yet fail to recognize other closely related lesions. The 1.8 Angstrom crystal structure of the monofunctional DNA glycosylase AlkA (E. coli 9-methyladenine-DNA glycosylase II) reveals a large hydrophobic cleft unusually rich in aromatic residues. An Asp residue projecting into this cleft is essential for catalysis, and it governs binding specificity for mechanism-based inhibitors. We propose that AlkA recognizes electron-deficient methylated bases through pi-donor/acceptor interactions involving the electron-rich aromatic cleft. Remarkably, AlkA is similar in fold and active site location to the bifunctional glycosylase/lyase endonuclease III, suggesting the two may employ fundamentally related mechanisms for base excision | - |
dc.identifier.bibliographicCitation | CELL, v.86, no.2, pp.321 - 329 | - |
dc.identifier.doi | 10.1016/S0092-8674(00)80103-8 | - |
dc.identifier.issn | 0092-8674 | - |
dc.identifier.scopusid | 2-s2.0-0030602838 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/21226 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0092867400801038 | - |
dc.identifier.wosid | A1996UZ97200017 | - |
dc.language | 영어 | - |
dc.publisher | CELL PRESS | - |
dc.title | Structural basis for the excision repair of alkylation-damaged DNA | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
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