Full metadata record
DC Field | Value | Language |
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dc.citation.endPage | 897 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 888 | - |
dc.citation.title | MOLECULES AND CELLS | - |
dc.citation.volume | 39 | - |
dc.contributor.author | Nair, Varun Sasidharan | - |
dc.contributor.author | Song, Mi Hye | - |
dc.contributor.author | Ko, Myunggon | - |
dc.contributor.author | Oh, Kwon Ik | - |
dc.date.accessioned | 2023-12-21T22:49:04Z | - |
dc.date.available | 2023-12-21T22:49:04Z | - |
dc.date.created | 2017-01-23 | - |
dc.date.issued | 2016-12 | - |
dc.description.abstract | Stable expression of Foxp3 is ensured by demethylation of CpG motifs in the Foxp3 intronic element, the conserved non-coding sequence 2 (CNS2), which persists throughout the lifespan of regulatory T cells (Tregs). However, little is known about the mechanisms on how CNS2 demethylation is sustained. In this study, we found that Ten-Eleven-Translocation (Tet) DNA dioxygenase protects the CpG motifs of CNS2 from re-methylation by DNA methyltransferases (Dnmts) and prevents Tregs from losing Foxp3 expression under inflammatory conditions. Upon stimulation of Tregs by interleukin-6 (IL6), Dnmt1 was recruited to CNS2 and induced methylation, which was inhibited by Tet2 recruited by IL2. Tet2 prevented CNS2 re-methylation by not only the occupancy of the CNS2 locus but also by its enzymatic activity. These results show that the CNS2 methylation status is dynamically regulated by a balance between Tets and Dnmts which influences the expression of Foxp3 in Tregs. Keywords: cytokine, DNA demethylation, Foxp3, regulatory T cell, Ten-Eleven-Translocation (Tet) |
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dc.identifier.bibliographicCitation | MOLECULES AND CELLS, v.39, no.12, pp.888 - 897 | - |
dc.identifier.doi | 10.14348/molcells.2016.0276 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.scopusid | 2-s2.0-85018391315 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/21216 | - |
dc.identifier.url | http://www.molcells.org/journal/view.html?doi=10.14348/molcells.2016.0276 | - |
dc.identifier.wosid | 000393179300007 | - |
dc.language | 영어 | - |
dc.publisher | KOREAN SOC MOLECULAR & CELLULAR BIOLOGY | - |
dc.title | DNA Demethylation of the Foxp3 Enhancer Is Maintained through Modulation of Ten-Eleven-Translocation and DNA Methyltransferases | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology; Cell Biology | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology; Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | cytokine | - |
dc.subject.keywordAuthor | DNA demethylation | - |
dc.subject.keywordAuthor | Foxp3 | - |
dc.subject.keywordAuthor | regulatory T cell | - |
dc.subject.keywordAuthor | Ten-Eleven-Translocation (Tet) | - |
dc.subject.keywordPlus | REGULATORY T-CELLS | - |
dc.subject.keywordPlus | CIS-ELEMENT | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | STIMULATION | - |
dc.subject.keywordPlus | POPULATION | - |
dc.subject.keywordPlus | GENERATION | - |
dc.subject.keywordPlus | PLASTICITY | - |
dc.subject.keywordPlus | STABILITY | - |
dc.subject.keywordPlus | LEADS | - |
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