Full metadata record
DC Field | Value | Language |
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dc.citation.endPage | 3245 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 3233 | - |
dc.citation.title | CELL REPORTS | - |
dc.citation.volume | 17 | - |
dc.contributor.author | Luo, Sarah X. | - |
dc.contributor.author | Timbang, Leah | - |
dc.contributor.author | Kim, Jae-Ick | - |
dc.contributor.author | Shang, Yulei | - |
dc.contributor.author | Sandoval, Kadellyn | - |
dc.contributor.author | Tang, Amy A. | - |
dc.contributor.author | Whistler, Jennifer L. | - |
dc.contributor.author | Ding, Jun B. | - |
dc.contributor.author | Huang, Eric J. | - |
dc.date.accessioned | 2023-12-21T22:50:07Z | - |
dc.date.available | 2023-12-21T22:50:07Z | - |
dc.date.created | 2016-12-27 | - |
dc.date.issued | 2016-12 | - |
dc.description.abstract | Neural circuits involving midbrain dopaminergic (DA) neurons regulate reward and goal-directed behaviors. Although local GABAergic input is known to modulate DA circuits, the mechanism that controls excitatory/inhibitory synaptic balance in DA neurons remains unclear. Here, we show that DA neurons use autocrine transforming growth factor β (TGF-β) signaling to promote the growth of axons and dendrites. Surprisingly, removing TGF-β type II receptor in DA neurons also disrupts the balance in TGF-β1 expression in DA neurons and neighboring GABAergic neurons, which increases inhibitory input, reduces excitatory synaptic input, and alters phasic firing patterns in DA neurons. Mice lacking TGF-β signaling in DA neurons are hyperactive and exhibit inflexibility in relinquishing learned behaviors and re-establishing new stimulus-reward associations. These results support a role for TGF-β in regulating the delicate balance of excitatory/inhibitory synaptic input in local microcircuits involving DA and GABAergic neurons and its potential contributions to neuropsychiatric disorders. | - |
dc.identifier.bibliographicCitation | CELL REPORTS, v.17, no.12, pp.3233 - 3245 | - |
dc.identifier.doi | 10.1016/j.celrep.2016.11.068 | - |
dc.identifier.issn | 2211-1247 | - |
dc.identifier.scopusid | 2-s2.0-85006785071 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/21062 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S2211124716316424 | - |
dc.identifier.wosid | 000390895600014 | - |
dc.language | 영어 | - |
dc.publisher | Cell Press | - |
dc.title | TGF-β Signaling in Dopaminergic Neurons Regulates Dendritic Growth, Excitatory-Inhibitory Synaptic Balance, and Reversal Learning | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | NEUROGENESIS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | DISRUPTION | - |
dc.subject.keywordPlus | RECEPTORS | - |
dc.subject.keywordPlus | BEHAVIOR | - |
dc.subject.keywordPlus | DEFECTS | - |
dc.subject.keywordPlus | APLYSIA | - |
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