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DC Field | Value | Language |
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dc.citation.endPage | 56 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 52 | - |
dc.citation.title | NEUROSCIENCE LETTERS | - |
dc.citation.volume | 500 | - |
dc.contributor.author | Min, Jung-Ah | - |
dc.contributor.author | Lee, Hye-Ryeon | - |
dc.contributor.author | Kim, Jae-Ick | - |
dc.contributor.author | Ju, Anes | - |
dc.contributor.author | Kim, Dai-Jin | - |
dc.contributor.author | Kaang, Bong-Kiun | - |
dc.date.accessioned | 2023-12-22T06:06:34Z | - |
dc.date.available | 2023-12-22T06:06:34Z | - |
dc.date.created | 2016-12-08 | - |
dc.date.issued | 2011-08 | - |
dc.description.abstract | Type 2 diabetes and chronic heavy alcohol consumption each have been known to be associated with the impairment of hippocampus-dependent cognitive functions. Although both conditions often coexist clinically and there is accumulated evidence of a relationship between the two, the combined effect on hippocampal long-term potentiation (LTP) has not yet been investigated. We compared the effect of type 2 diabetes itself with that of type 2 diabetes with chronic heavy alcohol consumption on the hippocampal LIP using Otsuka Long-Evans Tokushima Fatty (OLETF) rat model, which resembles the characteristics of human type 2 diabetes. Ten of 16-week-old male OLETF rats were randomized into two treatment groups according to weight: the OLETF-Alcohol (O-A, n=5) and the OLETF-Control (O-C, n=5). The rats in the O-A group were fed Lieber-DeCarli Regular EtOH over a 10-week period and the amount of alcohol consumption was 8.42 +/- 2.52 g/kg/day. To ensure the effect of poor glycemic control on LIP, intraperitoneal glucose tolerance test was performed after a 10-week treatment. The hippocampal LTP was measured by extracellular field excitatory post-synaptic potentials at Shaffer collateral (SC) synapses in the CA1 region. Although the O-A group showed significantly lower fasting and postprandial glucose (P<0.01 and P=0.02, respectively), the hippocampal LIP was more significantly attenuated in the O-A group than the O-C group (P=0.032). The results of this study suggested that chronic heavy alcohol consumption could potentiate the impairment of hippocampal LIP in individuals with impaired glucose tolerance or early type 2 diabetes, even though it did not aggravate, but did improve glycemic control. Clinical attention to chronic heavy drinking will be required in preventing cognitive impairment in individuals with type 2 diabetes. (C) 2011 Elsevier Ireland Ltd. All rights reserved | - |
dc.identifier.bibliographicCitation | NEUROSCIENCE LETTERS, v.500, no.1, pp.52 - 56 | - |
dc.identifier.doi | 10.1016/j.neulet.2011.05.239 | - |
dc.identifier.issn | 0304-3940 | - |
dc.identifier.scopusid | 2-s2.0-79960288571 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/20973 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0304394011008780 | - |
dc.identifier.wosid | 000294087600011 | - |
dc.language | 영어 | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.title | Impairment of long-term potentiation in the hippocampus of alcohol-treated OLETF rats | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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