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DC Field | Value | Language |
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dc.citation.startPage | 16 | - |
dc.citation.title | MOLECULAR BRAIN | - |
dc.citation.volume | 9 | - |
dc.contributor.author | Kim, Somi | - |
dc.contributor.author | Kim, TaeHyun | - |
dc.contributor.author | Lee, Hye-Ryeon | - |
dc.contributor.author | Jang, Eun-Hye | - |
dc.contributor.author | Ryu, Hyun-Hee | - |
dc.contributor.author | Kang, Minkyung | - |
dc.contributor.author | Rah, So-Young | - |
dc.contributor.author | Yoo, Juyoun | - |
dc.contributor.author | Lee, Bolam | - |
dc.contributor.author | Kim, Jae-Ick | - |
dc.contributor.author | Lim, Chae Seok | - |
dc.contributor.author | Kim, Sang Jeong | - |
dc.contributor.author | Kim, Uh-Hyun | - |
dc.contributor.author | Lee, Yong-Seok | - |
dc.contributor.author | Kaang, Bong-Kiun | - |
dc.date.accessioned | 2023-12-22T00:09:08Z | - |
dc.date.available | 2023-12-22T00:09:08Z | - |
dc.date.created | 2016-12-08 | - |
dc.date.issued | 2016-02 | - |
dc.description.abstract | CD38 is an enzyme that catalyzes the formation of cyclic ADP ribose and nicotinic acid adenine dinucleotide phosphate, both of which are involved in the mobilization of Ca2+ from intracellular stores. Recently, CD38 has been shown to regulate oxytocin release from hypothalamic neurons. Importantly, CD38 mutations are associated with autism spectrum disorders (ASD) and CD38 knockout (CD38(-/-)) mice display ASD-like behavioral phenotypes including deficient parental behavior and poor social recognition memory. Although ASD and learning deficits commonly co-occur, the role of CD38 in learning and memory has not been investigated. We report that CD38(-/-)mice show deficits in various learning and memory tasks such as the Morris water maze, contextual fear conditioning, and the object recognition test. However, either long-term potentiation or long-term depression is not impaired in the hippocampus of CD38(-/-)mice. Our results provide convincing evidence that CD38(-/-)mice show deficits in various learning and memory tasks including spatial and non-spatial memory tasks. Our data demonstrate that CD38 is critical for regulating hippocampus-dependent learning and memory without modulating synaptic plasticity. | - |
dc.identifier.bibliographicCitation | MOLECULAR BRAIN, v.9, pp.16 | - |
dc.identifier.doi | 10.1186/s13041-016-0195-5 | - |
dc.identifier.issn | 1756-6606 | - |
dc.identifier.scopusid | 2-s2.0-84959528435 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/20940 | - |
dc.identifier.url | http://molecularbrain.biomedcentral.com/articles/10.1186/s13041-016-0195-5 | - |
dc.identifier.wosid | 000370018700004 | - |
dc.language | 영어 | - |
dc.publisher | BIOMED CENTRAL LTD | - |
dc.title | Impaired learning and memory in CD38 null mutant mice | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | PERIRHINAL CORTICAL PLASTICITY | - |
dc.subject.keywordPlus | CYCLIC ADP-RIBOSE | - |
dc.subject.keywordPlus | RECOGNITION MEMORY | - |
dc.subject.keywordPlus | SYNAPTIC PLASTICITY | - |
dc.subject.keywordPlus | SPATIAL MEMORY | - |
dc.subject.keywordPlus | OXYTOCIN SECRETION | - |
dc.subject.keywordPlus | SOCIAL-BEHAVIOR | - |
dc.subject.keywordPlus | AUTISM | - |
dc.subject.keywordPlus | HIPPOCAMPUS | - |
dc.subject.keywordPlus | CALCIUM | - |
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