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- Bielawski, Christopher W.
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Synthesis of Degradable Poly[(Ethylene Glycol)-co-(Glycolic Acid)] via the Post-Polymerization Oxyfunctionalization of Poly(Ethylene Glycol)
- Author(s)
- Liu, Di, Bielawski, Christopher W.
- Issued Date
- 2016-10
- Citation
- MACROMOLECULAR RAPID COMMUNICATIONS, v.37, no.19, pp.1587 - 1592
- Abstract
- To enhance the limited degradability of poly(ethylene glycol) (PEG), a straightforward method of synthesizing poly[(ethylene glycol)-co-(glycolic acid)] (P(EG-co-GA)) via a ruthenium-catalyzed, post-polymerization oxyfunctionalization of various PEGs is developed. Using this method, a set of copolymers with GA compositions of up to 8 mol% are prepared with minimal reduction in molecular weight (<10%) when compared to their commercially available starting materials. The P(EG-co-GA) copolymers are shown to undergo hydrolysis under mild conditions. (Figure presented.).
- Publisher
- WILEY-V C H VERLAG GMBH
- ISSN
- 1022-1336
- Keyword (Author)
- biodegradable polymers, drug delivery systems, poly(ethylene glycol), post-polymerization modification, ruthenium
- Keyword
- DRUG-DELIVERY, RUTHENIUM TETROXIDE, PEGYLATION, OXIDATION, PEG, THERAPEUTICS
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