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DC Field | Value | Language |
---|---|---|
dc.citation.number | 9 | - |
dc.citation.startPage | 1014 | - |
dc.citation.title | NATURE GENETICS | - |
dc.citation.volume | 48 | - |
dc.contributor.author | Zhang, Xiaotian | - |
dc.contributor.author | Su, Jianzhong | - |
dc.contributor.author | Jeong, Mira | - |
dc.contributor.author | Ko, Myunggon | - |
dc.contributor.author | Huang, Yun | - |
dc.contributor.author | Park, Hyun Jung | - |
dc.contributor.author | Guzman, Anna | - |
dc.contributor.author | Lei, Yong | - |
dc.contributor.author | Huang, Yung-Hsin | - |
dc.contributor.author | Rao, Anjana | - |
dc.contributor.author | Li, Wei | - |
dc.contributor.author | Goodall, Margaret A. | - |
dc.date.accessioned | 2023-12-21T23:13:43Z | - |
dc.date.available | 2023-12-21T23:13:43Z | - |
dc.date.created | 2016-09-30 | - |
dc.date.issued | 2016-09 | - |
dc.description.abstract | Mutations in the epigenetic modifiers DNMT3A and TET2 non-randomly co-occur in lymphoma and leukemia despite their epistasis in the methylation-hydroxymethylation pathway. Using Dnmt3a and Tet2 double-knockout mice in which the development of malignancy is accelerated, we show that the double-knockout methylome reflects regions of independent, competitive and cooperative activity. Expression of lineage-specific transcription factors, including the erythroid regulators Klf1 and Epor, is upregulated in double-knockout hematopoietic stem cells (HSCs). DNMT3A and TET2 both repress Klf1, suggesting a model of cooperative inhibition by epigenetic modifiers. These data demonstrate a dual role for TET2 in promoting and inhibiting HSC differentiation, the loss of which, along with DNMT3A, obstructs differentiation, leading to transformation | - |
dc.identifier.bibliographicCitation | NATURE GENETICS, v.48, no.9, pp.1014 | - |
dc.identifier.doi | 10.1038/ng.3610 | - |
dc.identifier.issn | 1061-4036 | - |
dc.identifier.scopusid | 2-s2.0-84978680214 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/20509 | - |
dc.identifier.url | http://www.nature.com/ng/journal/v48/n9/full/ng.3610.html | - |
dc.identifier.wosid | 000382398800011 | - |
dc.language | 영어 | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | EPIGENETIC REGULATORS | - |
dc.subject.keywordPlus | CLONAL HEMATOPOIESIS | - |
dc.subject.keywordPlus | B-CELL | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.subject.keywordPlus | DNA | - |
dc.subject.keywordPlus | 5-HYDROXYMETHYLCYTOSINE | - |
dc.subject.keywordPlus | LEADS | - |
dc.subject.keywordPlus | MOUSE | - |
dc.subject.keywordPlus | 5-METHYLCYTOSINE | - |
dc.subject.keywordPlus | HYPERMETHYLATION | - |
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