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Lee, Ja Yil
School of Life Sciences
Research Interests
  • Investigated eukaryotic homologous recombination.

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Assembly of DNA Curtains Using Hydrogen Silsesquioxane As a Barrier to Lipid Diffusion

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Title
Assembly of DNA Curtains Using Hydrogen Silsesquioxane As a Barrier to Lipid Diffusion
Author
Fazio, T. A.Lee, Ja YilWind, S. J.Greene, E. C.
Issue Date
2012-09
Publisher
AMER CHEMICAL SOC
Citation
ANALYTICAL CHEMISTRY, v.84, no.18, pp.7613 - 7617
Abstract
We have established a single-molecule imaging experimental platform called "DNA curtains" in which DNA molecules tethered to a lipid bilayer are organized into patterns at nanofabricated metallic barriers on the surface of a microfluidic sample chamber. This technology has wide applications for real-time single-molecule imaging of protein nucleic acid interactions. Here, we demonstrate that DNA curtains can also be made from hydrogen silsesquioxane (HSQ). HSQ offers important advantages over metallic barriers because it can be lithographically patterned directly onto fused silica slides without any requirement for further processing steps, thereby offering the potential for rapid prototype development and/or scale up for manufacturing
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DOI
10.1021/ac302149g
ISSN
0003-2700
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SLS_Journal Papers
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