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김은희

Kim, Eunhee
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Phosphorylation of EZH2 Activates STAT3 Signaling via STAT3 Methylation and Promotes Tumorigenicity of Glioblastoma Stem-like Cells

Author(s)
Kim, EunheeKim, MisukWoo, Dong-HunShin, YongjaeShin, JihyeChang, NakhoOh, Young TaekKim, HongRheey, JingeunNakano, IchiroLee, CheoljuJoo, Kyeung MinRich, Jeremy N.Nam, Do-HyunLee, Jeongwu
Issued Date
2013-06
DOI
10.1016/j.ccr.2013.04.008
URI
https://scholarworks.unist.ac.kr/handle/201301/20170
Fulltext
http://www.sciencedirect.com/science/article/pii/S1535610813001773
Citation
CANCER CELL, v.23, no.6, pp.839 - 852
Abstract
Glioblastoma multiforme (GBM) displays cellular hierarchies harboring a subpopulation of stem-like cells (GSCs). Enhancer of Zeste Homo log 2 (EZH2), the lysine methyltransferase of Polycomb repressive complex 2, mediates transcriptional repression of prodifferentiation genes in both normal and neoplastic stem cells. An oncogenic role of EZH2 as a transcriptional silencer is well established; however, additional functions of EZH2 are incompletely understood. Here, we show that EZH2 binds to and methylates STAT3, leading to enhanced STAT3 activity by increased tyrosine phosphorylation of STAT3. The EZH2-STAT3 interaction preferentially occurs in GSCs relative to non-stem bulk tumor cells, and it requires a specific phosphorylation of EZH2. Inhibition of EZH2 reverses the silencing of Polycomb target genes and diminishes STAT3 activity, suggesting therapeutic strategies
Publisher
CELL PRESS
ISSN
1535-6108
Keyword
TUMOR-INITIATING CELLSGROUP PROTEIN EZH2NF-KAPPA-BBRAIN-TUMORSCANCER-CELLSHISTONE METHYLTRANSFERASEDEVELOPMENTAL REGULATORSMEDIATED REPRESSIONPOLYCOMB COMPLEXPROSTATE-CANCER

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