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Total synthesis of IKD-8344
- Author(s)
- Kim, Woo Han, Hong, Sung Kil, Lim, Sang Min, Ju, Min-Ae, Jung, Soon Kyu, Kim, Yong Wook, Jung, Jae Hoon, Kwon, Min Sang, Lee, Eun
- Issued Date
- 2006-10
- Citation
- ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.45, no.42, pp.7072 - 7075
- Abstract
- Complete construction: The total synthesis of IKD-8344, a novel 28-membered ring macrodiolide antibiotic (see structure), was accomplished by employing Williamson ether synthesis, β-alkoxymethacrylate radical cyclization, and Yamaguchi lactonization reactions. This synthesis is another example of the application of β-alkoxymethacrylate radical cyclization reactions for the stereoselective construction of complex oxacyclic natural products.
- Publisher
- WILEY-V C H VERLAG GMBH
- ISSN
- 1433-7851
- Keyword (Author)
- anticancer agents, antifungal agents, macrodiolides, natural products, total synthesis
- Keyword
- STEREOSELECTIVE-SYNTHESIS
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