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Min, Kyung-Tai
Molecular & Cellular Neurobiology Lab(Min Lab)
Research Interests
  • adult neurogenesis; axon development; axon regeneration; protein stability; protein synthesis; Down syndrome; Alzheimer's disease;

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DSCR1 is required for both axonal growth cone extension and steering

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Title
DSCR1 is required for both axonal growth cone extension and steering
Author
Wang, WeiRai, AsitHur, Eun-MiSmilansky, ZeevChang, Karen T.Min, Kyung-Tai
Issue Date
2016-05
Publisher
ROCKEFELLER UNIV PRESS
Citation
JOURNAL OF CELL BIOLOGY, v.213, no.4, pp.451 - 462
Abstract
Local information processing in the growth cone is essential for correct wiring of the nervous system. As an axon navigates through the developing nervous system, the growth cone responds to extrinsic guidance cues by coordinating axon outgrowth with growth cone steering. It has become increasingly clear that axon extension requires proper actin polymerization dynamics, whereas growth cone steering involves local protein synthesis. However, molecular components integrating these two processes have not been identified. Here, we show that Down syndrome critical region 1 protein (DSCR1) controls axon outgrowth by modulating growth cone actin dynamics through regulation of cofilin activity (phospho/dephospho-cofilin). Additionally, DSCR1 mediates brain-derived neurotrophic factor-induced local protein synthesis and growth cone turning. Our study identifies DSCR1 as a key protein that couples axon growth and pathfinding by dually regulating actin dynamics and local protein synthesis.
URI
https://scholarworks.unist.ac.kr/handle/201301/19685
URL
http://jcb.rupress.org/content/213/4/451
DOI
10.1083/jcb.201510107
ISSN
0021-9525
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