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Kwak, Sang Kyu
Kyu’s MolSim Lab @ UNIST
Research Interests
  • Molecular modeling and simulation, statistical thermodynamics, molecular physics

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Dynamics of mitochondrial transport in axons

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Title
Dynamics of mitochondrial transport in axons
Author
Niescier, Robert F.Kwak, Sang KyuJoo, Se HunChang, Karen T.Min, Kyung-Tai
Issue Date
2016-05
Publisher
FRONTIERS RES FOUND
Citation
FRONTIERS IN CELLULAR NEUROSCIENCE, v.10, pp.123
Abstract
The polarized structure and long neurites of neurons pose a unique challenge for proper mitochondrial distribution. It is widely accepted that mitochondria move from the cell body to axon ends and vice versa; however, we have found that mitochondria originating from the axon ends moving in the retrograde direction never reach to the cell body, and only a limited number of mitochondria moving in the anterograde direction from the cell body arrive at the axon ends of mouse hippocampal neurons. Furthermore, we have derived a mathematical formula using the Fokker-Planck equation to characterize features of mitochondrial transport, and the equation could determine altered mitochondrial transport in axons overexpressing parkin. Our analysis will provide new insights into the dynamics of mitochondrial transport in axons of normal and unhealthy neurons.
URI
https://scholarworks.unist.ac.kr/handle/201301/19304
URL
http://journal.frontiersin.org/article/10.3389/fncel.2016.00123/full
DOI
10.3389/fncel.2016.00123
ISSN
1662-5102
Appears in Collections:
SLS_Journal Papers
ECHE_Journal Papers
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