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dc.citation.endPage | 337 | - |
dc.citation.number | 7407 | - |
dc.citation.startPage | 330 | - |
dc.citation.title | NATURE | - |
dc.citation.volume | 487 | - |
dc.contributor.author | Muzny, Donna M. | - |
dc.contributor.author | Bainbridge, Matthew N. | - |
dc.contributor.author | Chang, Kyle | - |
dc.contributor.author | Dinh, Huyen H. | - |
dc.contributor.author | Drummond, Jennifer A. | - |
dc.contributor.author | Fowler, Gerald | - |
dc.contributor.author | Kovar, Christie L. | - |
dc.contributor.author | Lewis, Lora R. | - |
dc.contributor.author | Morgan, Margaret B. | - |
dc.contributor.author | Newsham, Irene F. | - |
dc.contributor.author | Reid, Jeffrey G. | - |
dc.contributor.author | Santibanez, Jireh | - |
dc.contributor.author | Shinbrot, Eve | - |
dc.contributor.author | Trevino, Lisa R. | - |
dc.contributor.author | Wu, Yuan-Qing | - |
dc.contributor.author | Wang, Min | - |
dc.contributor.author | Gunaratne, Preethi | - |
dc.contributor.author | Donehower, Lawrence A. | - |
dc.contributor.author | Creighton, Chad J. | - |
dc.contributor.author | Wheeler, David A. | - |
dc.contributor.author | Gibbs, Richard A. | - |
dc.contributor.author | Lawrence, Michael S. | - |
dc.contributor.author | Voet, Douglas | - |
dc.contributor.author | Jing, Rui | - |
dc.contributor.author | Cibulskis, Kristian | - |
dc.contributor.author | Sivachenko, Andrey | - |
dc.contributor.author | Stojanov, Petar | - |
dc.contributor.author | McKenna, Aaron | - |
dc.contributor.author | Lander, Eric S. | - |
dc.contributor.author | Gabriel, Stacey | - |
dc.contributor.author | Getz, Gad | - |
dc.contributor.author | Ding, Li | - |
dc.contributor.author | Fulton, Robert S. | - |
dc.contributor.author | Koboldt, Daniel C. | - |
dc.contributor.author | Wylie, Todd | - |
dc.contributor.author | Walker, Jason | - |
dc.contributor.author | Dooling, David J. | - |
dc.contributor.author | Fulton, Lucinda | - |
dc.contributor.author | Delehaunty, Kim D. | - |
dc.contributor.author | Fronick, Catrina C. | - |
dc.contributor.author | Demeter, Ryan | - |
dc.contributor.author | Mardis, Elaine R. | - |
dc.contributor.author | Wilson, Richard K. | - |
dc.contributor.author | Chu, Andy | - |
dc.contributor.author | Chun, Hye-Jung E. | - |
dc.contributor.author | Mungall, Andrew J. | - |
dc.contributor.author | Pleasance, Erin | - |
dc.contributor.author | Robertson, A. Gordon | - |
dc.contributor.author | Stoll, Dominik | - |
dc.contributor.author | Balasundaram, Miruna | - |
dc.contributor.author | Birol, Inanc | - |
dc.contributor.author | Butterfield, Yaron S. N. | - |
dc.contributor.author | Chuah, Eric | - |
dc.contributor.author | Coope, Robin J. N. | - |
dc.contributor.author | Dhalla, Noreen | - |
dc.contributor.author | Guin, Ranabir | - |
dc.contributor.author | Hirst, Carrie | - |
dc.contributor.author | Hirst, Martin | - |
dc.contributor.author | Holt, Robert A. | - |
dc.contributor.author | Lee, Darlene | - |
dc.contributor.author | Li, Haiyan I. | - |
dc.contributor.author | Mayo, Michael | - |
dc.contributor.author | Moore, Richard A. | - |
dc.contributor.author | Schein, Jacqueline E. | - |
dc.contributor.author | Slobodan, Jared R. | - |
dc.contributor.author | Tam, Angela | - |
dc.contributor.author | Thiessen, Nina | - |
dc.contributor.author | Varhol, Richard | - |
dc.contributor.author | Zeng, Thomas | - |
dc.contributor.author | Zhao, Yongjun | - |
dc.contributor.author | Jones, Steven J. M. | - |
dc.contributor.author | Marra, Marco A. | - |
dc.contributor.author | Bass, Adam J. | - |
dc.contributor.author | Ramos, Alex H. | - |
dc.contributor.author | Saksena, Gordon | - |
dc.contributor.author | Cherniack, Andrew D. | - |
dc.contributor.author | Schumacher, Stephen E. | - |
dc.contributor.author | Tabak, Barbara | - |
dc.contributor.author | Carter, Scott L. | - |
dc.contributor.author | Pho, Nam H. | - |
dc.contributor.author | Nguyen, Huy | - |
dc.contributor.author | Onofrio, Robert C. | - |
dc.contributor.author | Crenshaw, Andrew | - |
dc.contributor.author | Ardlie, Kristin | - |
dc.contributor.author | Beroukhim, Rameen | - |
dc.contributor.author | Winckler, Wendy | - |
dc.contributor.author | Meyerson, Matthew | - |
dc.contributor.author | Protopopov, Alexei | - |
dc.contributor.author | Zhang, Juinhua | - |
dc.contributor.author | Hadjipanayis, Angela | - |
dc.contributor.author | Lee, Eunjung | - |
dc.contributor.author | Xi, Ruibin | - |
dc.contributor.author | Yang, Lixing | - |
dc.contributor.author | Ren, Xiaojia | - |
dc.contributor.author | Zhang, Hailei | - |
dc.contributor.author | Sathiamoorthy, Narayanan | - |
dc.contributor.author | Shukla, Sachet | - |
dc.contributor.author | Chen, Peng-Chieh | - |
dc.contributor.author | Haseley, Psalm | - |
dc.contributor.author | Xiao, Yonghong | - |
dc.contributor.author | Lee, Semin | - |
dc.contributor.author | Seidman, Jonathan | - |
dc.contributor.author | Chin, Lynda | - |
dc.contributor.author | Park, Peter J. | - |
dc.contributor.author | Kucherlapati, Raju | - |
dc.contributor.author | Auman, J. Todd | - |
dc.contributor.author | Hoadley, Katherine A. | - |
dc.contributor.author | Du, Ying | - |
dc.contributor.author | Wilkerson, Matthew D. | - |
dc.contributor.author | Shi, Yan | - |
dc.contributor.author | Liquori, Christina | - |
dc.contributor.author | Meng, Shaowu | - |
dc.contributor.author | Li, Ling | - |
dc.contributor.author | Turman, Yidi J. | - |
dc.contributor.author | Topal, Michael D. | - |
dc.contributor.author | Tan, Donghui | - |
dc.contributor.author | Waring, Scot | - |
dc.contributor.author | Buda, Elizabeth | - |
dc.contributor.author | Walsh, Jesse | - |
dc.contributor.author | Jones, Corbin D. | - |
dc.contributor.author | Mieczkowski, Piotr A. | - |
dc.contributor.author | Singh, Darshan | - |
dc.contributor.author | Wu, Junyuan | - |
dc.contributor.author | Gulabani, Anisha | - |
dc.contributor.author | Dolina, Peter | - |
dc.contributor.author | Bodenheimer, Tom | - |
dc.contributor.author | Hoyle, Alan P. | - |
dc.contributor.author | Simons, Janae V. | - |
dc.contributor.author | Soloway, Matthew | - |
dc.contributor.author | Mose, Lisle E. | - |
dc.contributor.author | Jefferys, Stuart R. | - |
dc.contributor.author | Balu, Saianand | - |
dc.contributor.author | O'Connor, Brian D. | - |
dc.contributor.author | Prins, Jan F. | - |
dc.contributor.author | Chiang, Derek Y. | - |
dc.contributor.author | Hayes, D. Neil | - |
dc.contributor.author | Perou, Charles M. | - |
dc.contributor.author | Hinoue, Toshinori | - |
dc.contributor.author | Weisenberger, Daniel J. | - |
dc.contributor.author | Maglinte, Dennis T. | - |
dc.contributor.author | Pan, Fei | - |
dc.contributor.author | Berman, Benjamin P. | - |
dc.contributor.author | Van den Berg, David J. | - |
dc.contributor.author | Shen, Hui | - |
dc.contributor.author | Jr, Timothy Triche | - |
dc.contributor.author | Baylin, Stephen B. | - |
dc.contributor.author | Laird, Peter W. | - |
dc.contributor.author | Noble, Michael | - |
dc.contributor.author | Voet, Doug | - |
dc.contributor.author | Gehlenborg, Nils | - |
dc.contributor.author | DiCara, Daniel | - |
dc.contributor.author | Wu, Chang-Jiun | - |
dc.contributor.author | Liu, Spring Yingchun | - |
dc.contributor.author | Zhou, Lihua | - |
dc.contributor.author | Lin, Pei | - |
dc.contributor.author | Park, Richard W. | - |
dc.contributor.author | Nazaire, Marc-Danie | - |
dc.contributor.author | Robinson, Jim | - |
dc.contributor.author | Thorvaldsdottir, Helga | - |
dc.contributor.author | Mesirov, Jill | - |
dc.contributor.author | Thorsson, Vesteinn | - |
dc.contributor.author | Reynolds, Sheila M. | - |
dc.contributor.author | Bernard, Brady | - |
dc.contributor.author | Kreisberg, Richard | - |
dc.contributor.author | Lin, Jake | - |
dc.contributor.author | Iype, Lisa | - |
dc.contributor.author | Bressler, Ryan | - |
dc.contributor.author | Erkkilae, Timo | - |
dc.contributor.author | Gundapuneni, Madhumati | - |
dc.contributor.author | Liu, Yuexin | - |
dc.contributor.author | Norberg, Adam | - |
dc.contributor.author | Robinson, Tom | - |
dc.contributor.author | Da Yang | - |
dc.contributor.author | Zhang, Wei | - |
dc.contributor.author | Shmulevich, Ilya | - |
dc.contributor.author | De Ronde, Jorma J. | - |
dc.contributor.author | Schultz, Nikolaus | - |
dc.contributor.author | Cerami, Ethan | - |
dc.contributor.author | Ciriello, Giovanni | - |
dc.contributor.author | Goldberg, Arthur P. | - |
dc.contributor.author | Gross, Benjamin | - |
dc.contributor.author | Jacobsen, Anders | - |
dc.contributor.author | Gao, Jianjiong | - |
dc.contributor.author | Kaczkowski, Bogumil | - |
dc.contributor.author | Sinha, Rileen | - |
dc.contributor.author | Aksoy, B. Arman | - |
dc.contributor.author | Antipin, Yevgeniy | - |
dc.contributor.author | Reva, Boris | - |
dc.contributor.author | Shen, Ronglai | - |
dc.contributor.author | Taylor, Barry S. | - |
dc.contributor.author | Chan, Timothy A. | - |
dc.contributor.author | Ladanyi, Marc | - |
dc.contributor.author | Sander, Chris | - |
dc.contributor.author | Akbani, Rehan | - |
dc.contributor.author | Zhang, Nianxiang | - |
dc.contributor.author | Broom, Bradley M. | - |
dc.contributor.author | Casasent, Tod | - |
dc.contributor.author | Unruh, Anna | - |
dc.contributor.author | Wakefield, Chris | - |
dc.contributor.author | Hamilton, Stanley R. | - |
dc.contributor.author | Cason, R. Craig | - |
dc.contributor.author | Baggerly, Keith A. | - |
dc.contributor.author | Weinstein, John N. | - |
dc.contributor.author | Haussler, David | - |
dc.contributor.author | Benz, Christopher C. | - |
dc.contributor.author | Stuart, Joshua M. | - |
dc.contributor.author | Benz, Stephen C. | - |
dc.contributor.author | Sanborn, J. Zachary | - |
dc.contributor.author | Vaske, Charles J. | - |
dc.contributor.author | Zhu, Jingchun | - |
dc.contributor.author | Szeto, Christopher | - |
dc.contributor.author | Scott, Gary K. | - |
dc.contributor.author | Yau, Christina | - |
dc.contributor.author | Ng, Sam | - |
dc.contributor.author | Goldstein, Ted | - |
dc.contributor.author | Ellrott, Kyle | - |
dc.contributor.author | Collisson, Eric | - |
dc.contributor.author | Cozen, Aaron E. | - |
dc.contributor.author | Zerbino, Daniel | - |
dc.contributor.author | Wilks, Christopher | - |
dc.contributor.author | Craft, Brian | - |
dc.contributor.author | Spellman, Paul | - |
dc.contributor.author | Penny, Robert | - |
dc.contributor.author | Shelton, Troy | - |
dc.contributor.author | Hatfield, Martha | - |
dc.contributor.author | Morris, Scott | - |
dc.contributor.author | Yena, Peggy | - |
dc.contributor.author | Shelton, Candace | - |
dc.contributor.author | Sherman, Mark | - |
dc.contributor.author | Paulauskis, Joseph | - |
dc.contributor.author | Gastier-Foster, Julie M. | - |
dc.contributor.author | Bowen, Jay | - |
dc.contributor.author | Ramirez, Nilsa C. | - |
dc.contributor.author | Black, Aaron | - |
dc.contributor.author | Pyatt, Robert | - |
dc.contributor.author | Wise, Lisa | - |
dc.contributor.author | White, Peter | - |
dc.contributor.author | Bertagnolli, Monica | - |
dc.contributor.author | Brown, Jen | - |
dc.contributor.author | Chu, Gerald C. | - |
dc.contributor.author | Czerwinski, Christine | - |
dc.contributor.author | Denstman, Fred | - |
dc.contributor.author | Dhir, Rajiv | - |
dc.contributor.author | Doerner, Arnulf | - |
dc.contributor.author | Fuchs, Charles S. | - |
dc.contributor.author | Guillem, Jose G. | - |
dc.contributor.author | Iacocca, Mary | - |
dc.contributor.author | Juhl, Hartmut | - |
dc.contributor.author | Kaufman, Andrew | - |
dc.contributor.author | Kohl, Bernard, III | - |
dc.contributor.author | Van Le, Xuan | - |
dc.contributor.author | Mariano, Maria C. | - |
dc.contributor.author | Medina, Elizabeth N. | - |
dc.contributor.author | Meyers, Michael | - |
dc.contributor.author | Nash, Garrett M. | - |
dc.contributor.author | Paty, Phillip B. | - |
dc.contributor.author | Petrelli, Nicholas | - |
dc.contributor.author | Rabeno, Brenda | - |
dc.contributor.author | Richards, William G. | - |
dc.contributor.author | Solit, David | - |
dc.contributor.author | Swanson, Pat | - |
dc.contributor.author | Temple, Larissa | - |
dc.contributor.author | Tepper, Joel E. | - |
dc.contributor.author | Thorp, Richard | - |
dc.contributor.author | Vakiani, Efsevia | - |
dc.contributor.author | Weiser, Martin R. | - |
dc.contributor.author | Willis, Joseph E. | - |
dc.contributor.author | Witkin, Gary | - |
dc.contributor.author | Zeng, Zhaoshi | - |
dc.contributor.author | Zinner, Michael J. | - |
dc.contributor.author | Zornig, Carsten | - |
dc.contributor.author | Jensen, Mark A. | - |
dc.contributor.author | Sfeir, Robert | - |
dc.contributor.author | Kahn, Ari B. | - |
dc.contributor.author | Chu, Anna L. | - |
dc.contributor.author | Kothiyal, Prachi | - |
dc.contributor.author | Wang, Zhining | - |
dc.contributor.author | Snyder, Eric E. | - |
dc.contributor.author | Pontius, Joan | - |
dc.contributor.author | Pihl, Todd D. | - |
dc.contributor.author | Ayala, Brenda | - |
dc.contributor.author | Backus, Mark | - |
dc.contributor.author | Walton, Jessica | - |
dc.contributor.author | Whitmore, Jon | - |
dc.contributor.author | Baboud, Julien | - |
dc.contributor.author | Berton, Dominique L. | - |
dc.contributor.author | Nicholls, Matthew C. | - |
dc.contributor.author | Srinivasan, Deepak | - |
dc.contributor.author | Raman, Rohini | - |
dc.contributor.author | Girshik, Stanley | - |
dc.contributor.author | Kigonya, Peter A. | - |
dc.contributor.author | Alonso, Shelley | - |
dc.contributor.author | Sanbhadti, Rashmi N. | - |
dc.contributor.author | Barletta, Sean P. | - |
dc.contributor.author | Greene, John M. | - |
dc.contributor.author | Pot, David A. | - |
dc.contributor.author | Shaw, Kenna R. Mills | - |
dc.contributor.author | Dillon, Laura A. L. | - |
dc.contributor.author | Buetow, Ken | - |
dc.contributor.author | Davidsen, Tanja | - |
dc.contributor.author | Demchok, John A. | - |
dc.contributor.author | Eley, Greg | - |
dc.contributor.author | Ferguson, Martin | - |
dc.contributor.author | Fielding, Peter | - |
dc.contributor.author | Schaefer, Carl | - |
dc.contributor.author | Sheth, Margi | - |
dc.contributor.author | Yang, Liming | - |
dc.contributor.author | Guyer, Mark S. | - |
dc.contributor.author | Ozenberger, Bradley A. | - |
dc.contributor.author | Palchik, Jacqueline D. | - |
dc.contributor.author | Peterson, Jane | - |
dc.contributor.author | Sofia, Heidi J. | - |
dc.contributor.author | Thomson, Elizabeth | - |
dc.date.accessioned | 2023-12-22T05:06:30Z | - |
dc.date.available | 2023-12-22T05:06:30Z | - |
dc.date.created | 2016-03-28 | - |
dc.date.issued | 2012-07 | - |
dc.description.abstract | To characterize somatic alterations in colorectal carcinoma, we conducted a genome-scale analysis of 276 samples, analysing exome sequence, DNA copy number, promoter methylation and messenger RNA and microRNA expression. A subset of these samples (97) underwent low-depth-of-coverage whole-genome sequencing. In total, 16% of colorectal carcinomas were found to be hypermutated: three-quarters of these had the expected high microsatellite instability, usually with hypermethylation and MLH1 silencing, and one-quarter had somatic mismatch-repair gene and polymerase e (POLE) mutations. Excluding the hypermutated cancers, colon and rectum cancers were found to have considerably similar patterns of genomic alteration. Twenty-four genes were significantly mutated, and in addition to the expected APC, TP53, SMAD4, PIK3CA and KRAS mutations, we found frequent mutations in ARID1A, SOX9 and FAM123B. Recurrent copy-number alterations include potentially drug-targetable amplifications of ERBB2 and newly discovered amplification of IGF2. Recurrent chromosomal translocations include the fusion of NAV2 and WNT pathway member TCF7L1. Integrative analyses suggest new markers for aggressive colorectal carcinoma and an important role for MYC-directed transcriptional activation and repression | - |
dc.identifier.bibliographicCitation | NATURE, v.487, no.7407, pp.330 - 337 | - |
dc.identifier.doi | 10.1038/nature11252 | - |
dc.identifier.issn | 0028-0836 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/18889 | - |
dc.identifier.url | http://www.nature.com/nature/journal/v487/n7407/full/nature11252.html | - |
dc.identifier.wosid | 000306506500035 | - |
dc.language | 영어 | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Comprehensive molecular characterization of human colon and rectal cancer | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | COLORECTAL-CANCER | - |
dc.subject.keywordPlus | INTESTINAL EPITHELIUM | - |
dc.subject.keywordPlus | SOMATIC MUTATIONS | - |
dc.subject.keywordPlus | HUMAN BREAST | - |
dc.subject.keywordPlus | WILMS-TUMOR | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | ONCOGENE | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | WTX | - |
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