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DC Field | Value | Language |
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dc.citation.endPage | 525 | - |
dc.citation.number | 7417 | - |
dc.citation.startPage | 519 | - |
dc.citation.title | NATURE | - |
dc.citation.volume | 489 | - |
dc.contributor.author | Hammerman, Peter S. | - |
dc.contributor.author | Lawrence, Michael S. | - |
dc.contributor.author | Voet, Douglas | - |
dc.contributor.author | Jing, Rui | - |
dc.contributor.author | Cibulskis, Kristian | - |
dc.contributor.author | Sivachenko, Andrey | - |
dc.contributor.author | Stojanov, Petar | - |
dc.contributor.author | McKenna, Aaron | - |
dc.contributor.author | Lander, Eric S. | - |
dc.contributor.author | Gabriel, Stacey | - |
dc.contributor.author | Getz, Gad | - |
dc.contributor.author | Sougnez, Carrie | - |
dc.contributor.author | Imielinski, Marcin | - |
dc.contributor.author | Helman, Elena | - |
dc.contributor.author | Hernandez, Bryan | - |
dc.contributor.author | Pho, Nam H. | - |
dc.contributor.author | Meyerson, Matthew | - |
dc.contributor.author | Chu, Andy | - |
dc.contributor.author | Chun, Hye-Jung E. | - |
dc.contributor.author | Mungall, Andrew J. | - |
dc.contributor.author | Pleasance, Erin | - |
dc.contributor.author | Robertson, A. Gordon | - |
dc.contributor.author | Sipahimalani, Payal | - |
dc.contributor.author | Stoll, Dominik | - |
dc.contributor.author | Balasundaram, Miruna | - |
dc.contributor.author | Birol, Inanc | - |
dc.contributor.author | Butterfield, Yaron S. N. | - |
dc.contributor.author | Chuah, Eric | - |
dc.contributor.author | Coope, Robin J. N. | - |
dc.contributor.author | Corbett, Richard | - |
dc.contributor.author | Dhalla, Noreen | - |
dc.contributor.author | Guin, Ranabir | - |
dc.contributor.author | Hirst, Anhe Carrie | - |
dc.contributor.author | Hirst, Martin | - |
dc.contributor.author | Holt, Robert A. | - |
dc.contributor.author | Lee, Darlene | - |
dc.contributor.author | Li, Haiyan I. | - |
dc.contributor.author | Mayo, Michael | - |
dc.contributor.author | Moore, Richard A. | - |
dc.contributor.author | Mungall, Karen | - |
dc.contributor.author | Nip, Ka Ming | - |
dc.contributor.author | Olshen, Adam | - |
dc.contributor.author | Schein, Jacqueline E. | - |
dc.contributor.author | Slobodan, Jared R. | - |
dc.contributor.author | Tam, Angela | - |
dc.contributor.author | Thiessen, Nina | - |
dc.contributor.author | Varhol, Richard | - |
dc.contributor.author | Zeng, Thomas | - |
dc.contributor.author | Zhao, Yongjun | - |
dc.contributor.author | Jones, Steven J. M. | - |
dc.contributor.author | Marra, Marco A. | - |
dc.contributor.author | Saksena, Gordon | - |
dc.contributor.author | Cherniack, Andrew D. | - |
dc.contributor.author | Schumacher, Stephen E. | - |
dc.contributor.author | Tabak, Barbara | - |
dc.contributor.author | Carter, Scott L. | - |
dc.contributor.author | Nguyen, Huy | - |
dc.contributor.author | Onofrio, Robert C. | - |
dc.contributor.author | Crenshaw, Andrew | - |
dc.contributor.author | Ardlie, Kristin | - |
dc.contributor.author | Beroukhim, Rameen | - |
dc.contributor.author | Winckler, Wendy | - |
dc.contributor.author | Protopopov, Alexei | - |
dc.contributor.author | Zhang, Jianhua | - |
dc.contributor.author | Hadjipanayis, Angela | - |
dc.contributor.author | Lee, Semin | - |
dc.contributor.author | Xi, Ruibin | - |
dc.contributor.author | Yang, Lixing | - |
dc.contributor.author | Ren, Xiaojia | - |
dc.contributor.author | Zhang, Hailei | - |
dc.contributor.author | Shukla, Sachet | - |
dc.contributor.author | Chen, Peng-Chieh | - |
dc.contributor.author | Haseley, Psalm | - |
dc.contributor.author | Lee, Eunjung | - |
dc.contributor.author | Chin, Lynda | - |
dc.contributor.author | Park, Peter J. | - |
dc.contributor.author | Kucherlapati, Raju | - |
dc.contributor.author | Socci, Nicholas D. | - |
dc.contributor.author | Liang, Yupu | - |
dc.contributor.author | Schultz, Nikolaus | - |
dc.contributor.author | Borsu, Laetitia | - |
dc.contributor.author | Lash, Alex E. | - |
dc.contributor.author | Viale, Agnes | - |
dc.contributor.author | Sander, Chris | - |
dc.contributor.author | Ladanyi, Marc | - |
dc.contributor.author | Auman, J. Todd | - |
dc.contributor.author | Hoadley, Katherine A. | - |
dc.contributor.author | Wilkerson, Matthew D. | - |
dc.contributor.author | Shi, Yan | - |
dc.contributor.author | Liquori, Christina | - |
dc.contributor.author | Meng, Shaowu | - |
dc.contributor.author | Li, Ling | - |
dc.contributor.author | Turman, Yidi J. | - |
dc.contributor.author | Topal, Michael D. | - |
dc.contributor.author | Tan, Donghui | - |
dc.contributor.author | Waring, Scot | - |
dc.contributor.author | Buda, Elizabeth | - |
dc.contributor.author | Walsh, Jesse | - |
dc.contributor.author | Jones, Corbin D. | - |
dc.contributor.author | Mieczkowski, Piotr A. | - |
dc.contributor.author | Singh, Darshan | - |
dc.contributor.author | Wu, Junyuan | - |
dc.contributor.author | Gulabani, Anisha | - |
dc.contributor.author | Dolina, Peter | - |
dc.contributor.author | Bodenheimer, Tom | - |
dc.contributor.author | Hoyle, Alan P. | - |
dc.contributor.author | Simons, Janae V. | - |
dc.contributor.author | Soloway, Matthew G. | - |
dc.contributor.author | Mose, Lisle E. | - |
dc.contributor.author | Jefferys, Stuart R. | - |
dc.contributor.author | Balu, Saianand | - |
dc.contributor.author | O'Connor, Brian D. | - |
dc.contributor.author | Prins, Jan F. | - |
dc.contributor.author | Liu, Jinze | - |
dc.contributor.author | Chiang, Derek Y. | - |
dc.contributor.author | Hayes, D. Neil | - |
dc.contributor.author | Perou, Charles M. | - |
dc.contributor.author | Cope, Leslie | - |
dc.contributor.author | Danilova, Ludmila | - |
dc.contributor.author | Weisenberger, Daniel J. | - |
dc.contributor.author | Maglinte, Dennis T. | - |
dc.contributor.author | Pan, Fei | - |
dc.contributor.author | Van den Berg, David J. | - |
dc.contributor.author | Triche, Timothy | - |
dc.contributor.author | Herman, James G. | - |
dc.contributor.author | Baylin, Stephen B. | - |
dc.contributor.author | Laird, Peter W. | - |
dc.contributor.author | Noble, Michael | - |
dc.contributor.author | Voet, Doug | - |
dc.contributor.author | Gehlenborg, Nils | - |
dc.contributor.author | DiCara, Daniel | - |
dc.contributor.author | Zhang, Jinhua | - |
dc.contributor.author | Wu, Chang-Jiun | - |
dc.contributor.author | Liu, Spring Yingchun | - |
dc.contributor.author | Zou, Lihua | - |
dc.contributor.author | Lin, Pei | - |
dc.contributor.author | Cho, Juok | - |
dc.contributor.author | Nazaire, Marc-Danie | - |
dc.contributor.author | Robinson, Jim | - |
dc.contributor.author | Thorvaldsdottir, Helga | - |
dc.contributor.author | Mesirov, Jill | - |
dc.contributor.author | Sinha, Rileen | - |
dc.contributor.author | Ciriello, Giovanni | - |
dc.contributor.author | Cerami, Ethan | - |
dc.contributor.author | Gross, Benjamin | - |
dc.contributor.author | Jacobsen, Anders | - |
dc.contributor.author | Gao, Jianjiong | - |
dc.contributor.author | Aksoy, B. Arman | - |
dc.contributor.author | Weinhold, Nils | - |
dc.contributor.author | Ramirez, Ricardo | - |
dc.contributor.author | Taylor, Barry S. | - |
dc.contributor.author | Antipin, Yevgeniy | - |
dc.contributor.author | Reva, Boris | - |
dc.contributor.author | Shen, Ronglai | - |
dc.contributor.author | Mo, Qianxing | - |
dc.contributor.author | Seshan, Venkatraman | - |
dc.contributor.author | Paik, Paul K. | - |
dc.contributor.author | Akbani, Rehan | - |
dc.contributor.author | Zhang, Nianxiang | - |
dc.contributor.author | Broom, Bradley M. | - |
dc.contributor.author | Casasent, Tod | - |
dc.contributor.author | Unruh, Anna | - |
dc.contributor.author | Wakefield, Chris | - |
dc.contributor.author | Cason, R. Craig | - |
dc.contributor.author | Baggerly, Keith A. | - |
dc.contributor.author | Weinstein, John N. | - |
dc.contributor.author | Haussler, David | - |
dc.contributor.author | Benz, Christopher C. | - |
dc.contributor.author | Stuart, Joshua M. | - |
dc.contributor.author | Zhu, Jingchun | - |
dc.contributor.author | Szeto, Christopher | - |
dc.contributor.author | Scott, Gary K. | - |
dc.contributor.author | Yau, Christina | - |
dc.contributor.author | Ng, Sam | - |
dc.contributor.author | Goldstein, Ted | - |
dc.contributor.author | Waltman, Peter | - |
dc.contributor.author | Sokolov, Artem | - |
dc.contributor.author | Ellrott, Kyle | - |
dc.contributor.author | Collisson, Eric A. | - |
dc.contributor.author | Zerbino, Daniel | - |
dc.contributor.author | Wilks, Christopher | - |
dc.contributor.author | Ma, Singer | - |
dc.contributor.author | Craft, Brian | - |
dc.contributor.author | Du, Ying | - |
dc.contributor.author | Cabanski, Christopher | - |
dc.contributor.author | Walter, Vonn | - |
dc.contributor.author | Marron, J. S. | - |
dc.contributor.author | Liu, Yufeng | - |
dc.contributor.author | Wang, Kai | - |
dc.contributor.author | Creighton, Chad J. | - |
dc.contributor.author | Zhang, Yiqun | - |
dc.contributor.author | Travis, William D. | - |
dc.contributor.author | Rekhtman, Natasha | - |
dc.contributor.author | Yi, Joanne | - |
dc.contributor.author | Aubry, Marie C. | - |
dc.contributor.author | Cheney, Richard | - |
dc.contributor.author | Dacic, Sanja | - |
dc.contributor.author | Flieder, Douglas | - |
dc.contributor.author | Funkhouser, William | - |
dc.contributor.author | Illei, Peter | - |
dc.contributor.author | Myers, Jerome | - |
dc.contributor.author | Tsao, Ming-Sound | - |
dc.contributor.author | Penny, Robert | - |
dc.contributor.author | Mallery, David | - |
dc.contributor.author | Shelton, Troy | - |
dc.contributor.author | Hatfield, Martha | - |
dc.contributor.author | Morris, Scott | - |
dc.contributor.author | Yena, Peggy | - |
dc.contributor.author | Shelton, Candace | - |
dc.contributor.author | Sherman, Mark | - |
dc.contributor.author | Paulauskis, Joseph | - |
dc.contributor.author | Govindan, Ramaswamy | - |
dc.contributor.author | Azodo, Ijeoma | - |
dc.contributor.author | Beer, David | - |
dc.contributor.author | Bose, Ron | - |
dc.contributor.author | Byers, Lauren A. | - |
dc.contributor.author | Carbone, David | - |
dc.contributor.author | Chang, Li-Wei | - |
dc.contributor.author | Chiang, Derek | - |
dc.contributor.author | Chun, Elizabeth | - |
dc.contributor.author | Collisson, Eric | - |
dc.contributor.author | Ding, Li | - |
dc.contributor.author | Heymach, John | - |
dc.contributor.author | Ida, Cristiane | - |
dc.contributor.author | Johnson, Bruce | - |
dc.contributor.author | Jurisica, Igor | - |
dc.contributor.author | Kaufman, Jacob | - |
dc.contributor.author | Kosari, Farhad | - |
dc.contributor.author | Kwiatkowski, David | - |
dc.contributor.author | Maher, Christopher A. | - |
dc.contributor.author | Mungall, Andy | - |
dc.contributor.author | Pao, William | - |
dc.contributor.author | Peifer, Martin | - |
dc.contributor.author | Robertson, Gordon | - |
dc.contributor.author | Rusch, Valerie | - |
dc.contributor.author | Siegfried, Jill | - |
dc.contributor.author | Stuart, Joshua | - |
dc.contributor.author | Thomas, Roman K. | - |
dc.contributor.author | Tomaszek, Sandra | - |
dc.contributor.author | Vaske, Charles | - |
dc.contributor.author | Weisenberger, Daniel | - |
dc.contributor.author | Wheeler, David | - |
dc.contributor.author | Wigle, Dennis A. | - |
dc.contributor.author | Yang, Ping | - |
dc.contributor.author | Zhang, Jianjua John | - |
dc.contributor.author | Jensen, Mark A. | - |
dc.contributor.author | Sfeir, Robert | - |
dc.contributor.author | Kahn, Ari B. | - |
dc.contributor.author | Chu, Anna L. | - |
dc.contributor.author | Kothiyal, Prachi | - |
dc.contributor.author | Wang, Zhining | - |
dc.contributor.author | Snyder, Eric E. | - |
dc.contributor.author | Pontius, Joan | - |
dc.contributor.author | Pihl, Todd D. | - |
dc.contributor.author | Ayala, Brenda | - |
dc.contributor.author | Backus, Mark | - |
dc.contributor.author | Walton, Jessica | - |
dc.contributor.author | Baboud, Julien | - |
dc.contributor.author | Berton, Dominique L. | - |
dc.contributor.author | Nicholls, Matthew C. | - |
dc.contributor.author | Srinivasan, Deepak | - |
dc.contributor.author | Raman, Rohini | - |
dc.contributor.author | Girshik, Stanley | - |
dc.contributor.author | Kigonya, Peter A. | - |
dc.contributor.author | Alonso, Shelley | - |
dc.contributor.author | Sanbhadti, Rashmi N. | - |
dc.contributor.author | Barletta, Sean P. | - |
dc.contributor.author | Greene, John M. | - |
dc.contributor.author | Pot, David A. | - |
dc.contributor.author | Bandarchi-Chamkhaleh, Bizhan | - |
dc.contributor.author | Boyd, Jeff | - |
dc.contributor.author | Weaver, JoEllen | - |
dc.contributor.author | Azodo, Ijeoma A. | - |
dc.contributor.author | Tomaszek, Sandra C. | - |
dc.contributor.author | Aubry, Marie Christine | - |
dc.contributor.author | Ida, Christiane M. | - |
dc.contributor.author | Brock, Malcolm V. | - |
dc.contributor.author | Rogers, Kristen | - |
dc.contributor.author | Rutledge, Marian | - |
dc.contributor.author | Brown, Travis | - |
dc.contributor.author | Lee, Beverly | - |
dc.contributor.author | Shin, James | - |
dc.contributor.author | Trusty, Dante | - |
dc.contributor.author | Dhir, Rajiv | - |
dc.contributor.author | Siegfried, Jill M. | - |
dc.contributor.author | Potapova, Olga | - |
dc.contributor.author | Fedosenko, Konstantin V. | - |
dc.contributor.author | Nemirovich-Danchenko, Elena | - |
dc.contributor.author | Zakowski, Maureen | - |
dc.contributor.author | Iacocca, Mary V. | - |
dc.contributor.author | Brown, Jennifer | - |
dc.contributor.author | Rabeno, Brenda | - |
dc.contributor.author | Czerwinski, Christine | - |
dc.contributor.author | Petrelli, Nicholas | - |
dc.contributor.author | Fan, Zhen | - |
dc.contributor.author | Todaro, Nicole | - |
dc.contributor.author | Eckman, John | - |
dc.contributor.author | Rathmell, W. Kimryn | - |
dc.contributor.author | Thorne, Leigh B. | - |
dc.contributor.author | Huang, Mei | - |
dc.contributor.author | Boice, Lori | - |
dc.contributor.author | Hill, Ashley | - |
dc.contributor.author | Curley, Erin | - |
dc.contributor.author | Morrison, Carl | - |
dc.contributor.author | Gaudioso, Carmelo | - |
dc.contributor.author | Bartlett, Johnm. S. | - |
dc.contributor.author | Kodeeswaran, Sugy | - |
dc.contributor.author | Zanke, Brent | - |
dc.contributor.author | Sekhon, Harman | - |
dc.contributor.author | David, Kerstin | - |
dc.contributor.author | Juhl, Hartmut | - |
dc.contributor.author | Van Le, Xuan | - |
dc.contributor.author | Kohl, Bernard | - |
dc.contributor.author | Thorp, Richard | - |
dc.contributor.author | Tien, Nguyen Viet | - |
dc.contributor.author | Van Bang, Nguyen | - |
dc.contributor.author | Sussman, Howard | - |
dc.contributor.author | Phu, Bui Duc | - |
dc.contributor.author | Hajek, Richard | - |
dc.contributor.author | PhiHung, Nguyen | - |
dc.contributor.author | Khan, Khurram Z. | - |
dc.contributor.author | Muley, Thomas | - |
dc.contributor.author | Shaw, Kenna R. Mills | - |
dc.contributor.author | Sheth, Margi | - |
dc.contributor.author | Yang, Liming | - |
dc.contributor.author | Buetow, Ken | - |
dc.contributor.author | Davidsen, Tanja | - |
dc.contributor.author | Demchok, John A. | - |
dc.contributor.author | Eley, Greg | - |
dc.contributor.author | Ferguson, Martin | - |
dc.contributor.author | Dillon, Laura A. L. | - |
dc.contributor.author | Schaefer, Carl | - |
dc.contributor.author | Guyer, Mark S. | - |
dc.contributor.author | Ozenberger, Bradley A. | - |
dc.contributor.author | Palchik, Jacqueline D. | - |
dc.contributor.author | Peterson, Jane | - |
dc.contributor.author | Sofia, Heidi J. | - |
dc.contributor.author | Thomson, Elizabeth | - |
dc.date.accessioned | 2023-12-22T04:42:12Z | - |
dc.date.available | 2023-12-22T04:42:12Z | - |
dc.date.created | 2016-03-28 | - |
dc.date.issued | 2012-09 | - |
dc.description.abstract | Lung squamous cell carcinoma is a common type of lung cancer, causing approximately 400,000 deaths per year worldwide. Genomic alterations in squamous cell lung cancers have not been comprehensively characterized, and no molecularly targeted agents have been specifically developed for its treatment. As part of The Cancer Genome Atlas, here we profile 178 lung squamous cell carcinomas to provide a comprehensive landscape of genomic and epigenomic alterations. We show that the tumour type is characterized by complex genomic alterations, with a mean of 360 exonic mutations, 165 genomic rearrangements, and 323 segments of copy number alteration per tumour. We find statistically recurrent mutations in 11 genes, including mutation of TP53 in nearly all specimens. Previously unreported loss-of-function mutations are seen in the HLA-A class I major histocompatibility gene. Significantly altered pathways included NFE2L2 and KEAP1 in 34%, squamous differentiation genes in 44%, phosphatidylinositol-3-OH kinase pathway genes in 47%, and CDKN2A and RB1 in 72% of tumours. We identified a potential therapeutic target in most tumours, offering new avenues of investigation for the treatment of squamous cell lung cancers | - |
dc.identifier.bibliographicCitation | NATURE, v.489, no.7417, pp.519 - 525 | - |
dc.identifier.doi | 10.1038/nature11404 | - |
dc.identifier.issn | 0028-0836 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/18888 | - |
dc.identifier.url | http://www.nature.com/nature/journal/v489/n7417/full/nature11404.html | - |
dc.identifier.wosid | 000309167100041 | - |
dc.language | 영어 | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Comprehensive genomic characterization of squamous cell lung cancers | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | COPY-NUMBER ALTERATION | - |
dc.subject.keywordPlus | THERAPEUTIC TARGET | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | GEFITINIB | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | FUSION | - |
dc.subject.keywordPlus | ADENOCARCINOMA | - |
dc.subject.keywordPlus | AMPLIFICATION | - |
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