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dc.citation.endPage | 73 | - |
dc.citation.number | 7447 | - |
dc.citation.startPage | 67 | - |
dc.citation.title | NATURE | - |
dc.citation.volume | 497 | - |
dc.contributor.author | Getz, Gad | - |
dc.contributor.author | Gabriel, Stacey B. | - |
dc.contributor.author | Cibulskis, Kristian | - |
dc.contributor.author | Lander, Eric | - |
dc.contributor.author | Sivachenko, Andrey | - |
dc.contributor.author | Sougnez, Carrie | - |
dc.contributor.author | Lawrence, Mike | - |
dc.contributor.author | Kandoth, Cyriac | - |
dc.contributor.author | Dooling, David | - |
dc.contributor.author | Fulton, Robert | - |
dc.contributor.author | Fulton, Lucinda | - |
dc.contributor.author | Kalicki-Veizer, Joelle | - |
dc.contributor.author | McLellan, Michael D. | - |
dc.contributor.author | O'Laughlin, Michelle | - |
dc.contributor.author | Schmidt, Heather | - |
dc.contributor.author | Wilson, Richard K. | - |
dc.contributor.author | Ye, Kai | - |
dc.contributor.author | Ding, Li | - |
dc.contributor.author | Mardis, Elaine R. | - |
dc.contributor.author | Ally, Adrian | - |
dc.contributor.author | Balasundaram, Miruna | - |
dc.contributor.author | Birol, Inanc | - |
dc.contributor.author | Butterfield, Yaron S. N. | - |
dc.contributor.author | Carlsen, Rebecca | - |
dc.contributor.author | Carter, Candace | - |
dc.contributor.author | Chu, Andy | - |
dc.contributor.author | Chuah, Eric | - |
dc.contributor.author | Chun, Hye-Jung E. | - |
dc.contributor.author | Dhalla, Noreen | - |
dc.contributor.author | Guin, Ranabir | - |
dc.contributor.author | Hirst, Carrie | - |
dc.contributor.author | Holt, Robert A. | - |
dc.contributor.author | Jones, Steven J. M. | - |
dc.contributor.author | Lee, Darlene | - |
dc.contributor.author | Li, Haiyan I. | - |
dc.contributor.author | Marra, Marco A. | - |
dc.contributor.author | Mayo, Michael | - |
dc.contributor.author | Moore, Richard A. | - |
dc.contributor.author | Mungall, Andrew J. | - |
dc.contributor.author | Plettner, Patrick | - |
dc.contributor.author | Schein, Jacqueline E. | - |
dc.contributor.author | Sipahimalani, Payal | - |
dc.contributor.author | Tam, Angela | - |
dc.contributor.author | Varhol, Richard J. | - |
dc.contributor.author | Robertson, A. Gordon | - |
dc.contributor.author | Pashtan, Itai | - |
dc.contributor.author | Saksena, Gordon | - |
dc.contributor.author | Onofrio, Robert C. | - |
dc.contributor.author | Schumacher, Steven E. | - |
dc.contributor.author | Tabak, Barbara | - |
dc.contributor.author | Carter, Scott L. | - |
dc.contributor.author | Hernandez, Bryan | - |
dc.contributor.author | Gentry, Jeff | - |
dc.contributor.author | Salvesen, Helga B. | - |
dc.contributor.author | Ardlie, Kristin | - |
dc.contributor.author | Winckler, Wendy | - |
dc.contributor.author | Beroukhim, Rameen | - |
dc.contributor.author | Meyerson, Matthew | - |
dc.contributor.author | Hadjipanayis, Angela | - |
dc.contributor.author | Lee, Semin | - |
dc.contributor.author | Mahadeshwar, Harshad S. | - |
dc.contributor.author | Park, Peter | - |
dc.contributor.author | Protopopov, Alexei | - |
dc.contributor.author | Ren, Xiaojia | - |
dc.contributor.author | Seth, Sahil | - |
dc.contributor.author | Song, Xingzhi | - |
dc.contributor.author | Tang, Jiabin | - |
dc.contributor.author | Xi, Ruibin | - |
dc.contributor.author | Yang, Lixing | - |
dc.contributor.author | Zeng, Dong | - |
dc.contributor.author | Kucherlapati, Raju | - |
dc.contributor.author | Chin, Lynda | - |
dc.contributor.author | Zhang, Jianhua | - |
dc.contributor.author | Auman, J. Todd | - |
dc.contributor.author | Balu, Saianand | - |
dc.contributor.author | Bodenheimer, Tom | - |
dc.contributor.author | Buda, Elizabeth | - |
dc.contributor.author | Hayes, D. Neil | - |
dc.contributor.author | Hoyle, Alan P. | - |
dc.contributor.author | Jefferys, Stuart R. | - |
dc.contributor.author | Jones, Corbin D. | - |
dc.contributor.author | Meng, Shaowu | - |
dc.contributor.author | Mieczkowski, Piotr A. | - |
dc.contributor.author | Mose, Lisle E. | - |
dc.contributor.author | Parker, Joel S. | - |
dc.contributor.author | Perou, Charles M. | - |
dc.contributor.author | Roach, Jeff | - |
dc.contributor.author | Shi, Yan | - |
dc.contributor.author | Simons, Janae V. | - |
dc.contributor.author | Soloway, Mathew G. | - |
dc.contributor.author | Tan, Donghui | - |
dc.contributor.author | Topal, Michael D. | - |
dc.contributor.author | Waring, Scot | - |
dc.contributor.author | Wu, Junyuan | - |
dc.contributor.author | Hoadley, Katherine A. | - |
dc.contributor.author | Baylin, Stephen B. | - |
dc.contributor.author | Bootwalla, Moiz S. | - |
dc.contributor.author | Lai, Phillip H. | - |
dc.contributor.author | Triche, Timothy J., Jr. | - |
dc.contributor.author | Van Den Berg, DavidJ. | - |
dc.contributor.author | Weisenberger, Daniel J. | - |
dc.contributor.author | Laird, Peter W. | - |
dc.contributor.author | Shen, Hui | - |
dc.contributor.author | Cho, Juok | - |
dc.contributor.author | DiCara, Daniel | - |
dc.contributor.author | Frazer, Scott | - |
dc.contributor.author | Heiman, David | - |
dc.contributor.author | Jing, Rui | - |
dc.contributor.author | Lin, Pei | - |
dc.contributor.author | Mallard, Will | - |
dc.contributor.author | Stojanov, Petar | - |
dc.contributor.author | Voet, Doug | - |
dc.contributor.author | Zhang, Hailei | - |
dc.contributor.author | Zou, Lihua | - |
dc.contributor.author | Noble, Michael | - |
dc.contributor.author | Reynolds, Sheila M. | - |
dc.contributor.author | Shmulevich, Ilya | - |
dc.contributor.author | Aksoy, B. Arman | - |
dc.contributor.author | Antipin, Yevgeniy | - |
dc.contributor.author | Ciriello, Giovanni | - |
dc.contributor.author | Dresdner, Gideon | - |
dc.contributor.author | Gao, Jianjiong | - |
dc.contributor.author | Gross, Benjamin | - |
dc.contributor.author | Jacobsen, Anders | - |
dc.contributor.author | Ladanyi, Marc | - |
dc.contributor.author | Reva, Boris | - |
dc.contributor.author | Sander, Chris | - |
dc.contributor.author | Sinha, Rileen | - |
dc.contributor.author | Sumer, S. Onur | - |
dc.contributor.author | Taylor, Barry S. | - |
dc.contributor.author | Cerami, Ethan | - |
dc.contributor.author | Weinhold, Nils | - |
dc.contributor.author | Schultz, Nikolaus | - |
dc.contributor.author | Shen, Ronglai | - |
dc.contributor.author | Benz, Stephen | - |
dc.contributor.author | Goldstein, Ted | - |
dc.contributor.author | Haussler, David | - |
dc.contributor.author | Sam Ng | - |
dc.contributor.author | Szeto, Christopher | - |
dc.contributor.author | Stuart, Joshua | - |
dc.contributor.author | Benz, Christopher C. | - |
dc.contributor.author | Yau, Christina | - |
dc.contributor.author | Zhang, Wei | - |
dc.contributor.author | Annala, Matti | - |
dc.contributor.author | Broom, Bradley M. | - |
dc.contributor.author | Casasent, Tod D. | - |
dc.contributor.author | Ju, Zhenlin | - |
dc.contributor.author | Liang, Han | - |
dc.contributor.author | Liu, Guoyan | - |
dc.contributor.author | Lu, Yiling | - |
dc.contributor.author | Unruh, Anna K. | - |
dc.contributor.author | Wakefield, Chris | - |
dc.contributor.author | Weinstein, John N. | - |
dc.contributor.author | Zhang, Nianxiang | - |
dc.contributor.author | Liu, Yuexin | - |
dc.contributor.author | Broaddus, Russell | - |
dc.contributor.author | Akbani, Rehan | - |
dc.contributor.author | Mills, Gordon B. | - |
dc.contributor.author | Adams, Christopher | - |
dc.contributor.author | Barr, Thomas | - |
dc.contributor.author | Black, Aaron D. | - |
dc.contributor.author | Bowen, Jay | - |
dc.contributor.author | Deardurff, John | - |
dc.contributor.author | Frick, Jessica | - |
dc.contributor.author | Gastier-Foster, Julie M. | - |
dc.contributor.author | Grossman, Thomas | - |
dc.contributor.author | Harper, Hollie A. | - |
dc.contributor.author | Hart-Kothari, Melissa | - |
dc.contributor.author | Helsel, Carmen | - |
dc.contributor.author | Hobensack, Aaron | - |
dc.contributor.author | Kuck, Harkness | - |
dc.contributor.author | Kneile, Kelley | - |
dc.contributor.author | Leraas, KristenM. | - |
dc.contributor.author | Lichtenberg, Tara M. | - |
dc.contributor.author | McAllister, Cynthia | - |
dc.contributor.author | Pyatt, Robert E. | - |
dc.contributor.author | Ramirez, Nilsa C. | - |
dc.contributor.author | Tabler, Teresa R. | - |
dc.contributor.author | Vanhoose, Nathan | - |
dc.contributor.author | White, Peter | - |
dc.contributor.author | Wise, Lisa | - |
dc.contributor.author | Zmuda, Erik | - |
dc.contributor.author | Barnabas, Nandita | - |
dc.contributor.author | Berry-Green, Charlenia | - |
dc.contributor.author | Blanc, Victoria | - |
dc.contributor.author | Boice, Lori | - |
dc.contributor.author | Button, Michael | - |
dc.contributor.author | Farkas, Adam | - |
dc.contributor.author | Green, Alex | - |
dc.contributor.author | MacKenzie, Jean | - |
dc.contributor.author | Nicholson, Dana | - |
dc.contributor.author | Kalloger, Steve E. | - |
dc.contributor.author | Gilks, C. Blake | - |
dc.contributor.author | Karlan, Beth Y. | - |
dc.contributor.author | Lester, Jenny | - |
dc.contributor.author | Orsulic, Sandra | - |
dc.contributor.author | Borowsky, Mark | - |
dc.contributor.author | Cadungog, Mark | - |
dc.contributor.author | Czerwinski, Christine | - |
dc.contributor.author | Huelsenbeck-Dill, Lori | - |
dc.contributor.author | Iacocca, Mary | - |
dc.contributor.author | Petrelli, Nicholas | - |
dc.contributor.author | Witkin, Gary | - |
dc.contributor.author | Nemirovich-Danchenko, Elena | - |
dc.contributor.author | Potapova, Olga | - |
dc.contributor.author | Rotin, Daniil | - |
dc.contributor.author | Berchuck, Andrew | - |
dc.contributor.author | Birrer, Michael | - |
dc.contributor.author | DiSaia, Phillip | - |
dc.contributor.author | Monovich, Laura | - |
dc.contributor.author | Curley, Erin | - |
dc.contributor.author | Gardner, Johanna | - |
dc.contributor.author | Mallery, David | - |
dc.contributor.author | Penny, Robert | - |
dc.contributor.author | Dowdy, Sean C. | - |
dc.contributor.author | Winterhoff, Boris | - |
dc.contributor.author | Dao, Linda | - |
dc.contributor.author | Gostout, Bobbie | - |
dc.contributor.author | Meuter, Alexandra | - |
dc.contributor.author | Teoman, Attila | - |
dc.contributor.author | Dao, Fanny | - |
dc.contributor.author | Olvera, Narciso | - |
dc.contributor.author | Bogomolniy, Faina | - |
dc.contributor.author | Garg, Karuna | - |
dc.contributor.author | Soslow, Robert A. | - |
dc.contributor.author | Levine, Douglas A. | - |
dc.contributor.author | Abramov, Mikhail | - |
dc.contributor.author | Bartlett, John M. S. | - |
dc.contributor.author | Kodeeswaran, Sugy | - |
dc.contributor.author | Parfitt, Jeremy | - |
dc.contributor.author | Moiseenko, Fedor | - |
dc.contributor.author | Clarke, Blaise A. | - |
dc.contributor.author | Goodman, Marc T. | - |
dc.contributor.author | Carney, Michael E. | - |
dc.contributor.author | Matsuno, Rayna K. | - |
dc.contributor.author | Fisher, Jennifer | - |
dc.contributor.author | Huang, Mei | - |
dc.contributor.author | Rathmell, W. Kimryn | - |
dc.contributor.author | Thorne, Leigh | - |
dc.contributor.author | Van Le, Linda | - |
dc.contributor.author | Dhir, Rajiv | - |
dc.contributor.author | Edwards, Robert | - |
dc.contributor.author | Elishaev, Esther | - |
dc.contributor.author | Zorn, Kristin | - |
dc.contributor.author | Goodfellow, Paul J. | - |
dc.contributor.author | Mutch, David | - |
dc.contributor.author | Cherniack, Andrew D. | - |
dc.contributor.author | Kahn, Ari B. | - |
dc.contributor.author | Bell, Daphne W. | - |
dc.contributor.author | Pollock, Pamela M. | - |
dc.contributor.author | Wang, Chen | - |
dc.contributor.author | Wheeler, David A. | - |
dc.contributor.author | Shinbrot, Eve | - |
dc.contributor.author | Ayala, Brenda | - |
dc.contributor.author | Chu, Anna L. | - |
dc.contributor.author | Jensen, Mark A. | - |
dc.contributor.author | Kothiyal, Prachi | - |
dc.contributor.author | Pihl, Todd D. | - |
dc.contributor.author | Pontius, Joan | - |
dc.contributor.author | Pot, David A. | - |
dc.contributor.author | Snyder, Eric E. | - |
dc.contributor.author | Srinivasan, Deepak | - |
dc.contributor.author | Shaw, Kenna R. Mills | - |
dc.contributor.author | Sheth, Margi | - |
dc.contributor.author | Davidsen, Tanja | - |
dc.contributor.author | Eley, Greg | - |
dc.contributor.author | Ferguson, Martin L. | - |
dc.contributor.author | Demchok, John A. | - |
dc.contributor.author | Yang, Liming | - |
dc.contributor.author | Guyer, Mark S. | - |
dc.contributor.author | Ozenberger, Bradley A. | - |
dc.contributor.author | Sofia, Heidi J. | - |
dc.date.accessioned | 2023-12-22T04:06:27Z | - |
dc.date.available | 2023-12-22T04:06:27Z | - |
dc.date.created | 2016-03-28 | - |
dc.date.issued | 2013-05 | - |
dc.description.abstract | We performed an integrated genomic, transcriptomic and proteomic characterization of 373 endometrial carcinomas using array- and sequencing-based technologies. Uterine seroustumours and similar to 25% of high-grade endometrioid tumours had extensive copy number alterations, few DNA methylation changes, low oestrogen receptor/progesterone receptor levels, and frequent TP53 mutations. Most endometrioid tumours had few copy number alterations or TP53 mutations, but frequent mutations in PTEN, CTNNB1, PIK3CA, ARID1A and KRAS and novel mutations in the SWI/SNF chromatin remodelling complex gene ARID5B. A subset of endometrioid tumours that we identified had a markedly increased transversion mutation frequency and newly identified hotspot mutations in POLE. Our results classified endometrial cancers into four categories: POLE ultramutated, microsatellite instability hypermutated, copy-number low, and copy-number high. Uterine serous carcinomas share genomic features with ovarian serous and basal-like breast carcinomas. We demonstrated that the genomic features of endometrial carcinomas permit a reclassification that may affect post-surgical adjuvant treatment for women with aggressive tumours | - |
dc.identifier.bibliographicCitation | NATURE, v.497, no.7447, pp.67 - 73 | - |
dc.identifier.doi | 10.1038/nature12113 | - |
dc.identifier.issn | 0028-0836 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/18887 | - |
dc.identifier.url | http://www.nature.com/nature/journal/v497/n7447/full/nature12113.html | - |
dc.identifier.wosid | 000318221500035 | - |
dc.language | 영어 | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Integrated genomic characterization of endometrial carcinoma | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | GYNECOLOGIC-ONCOLOGY-GROUP | - |
dc.subject.keywordPlus | MICROSATELLITE INSTABILITY | - |
dc.subject.keywordPlus | MATRIX FACTORIZATION | - |
dc.subject.keywordPlus | SOMATIC MUTATIONS | - |
dc.subject.keywordPlus | HIGH-FREQUENCY | - |
dc.subject.keywordPlus | LUNG-CANCER | - |
dc.subject.keywordPlus | TUMORS | - |
dc.subject.keywordPlus | COLON | - |
dc.subject.keywordPlus | DOXORUBICIN | - |
dc.subject.keywordPlus | PROTEIN | - |
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