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DC Field | Value | Language |
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dc.citation.endPage | 690 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 676 | - |
dc.citation.title | CELL | - |
dc.citation.volume | 159 | - |
dc.contributor.author | Agrawal, Nishant | - |
dc.contributor.author | Akbani, Rehan | - |
dc.contributor.author | Aksoy, B. Arman | - |
dc.contributor.author | Ally, Adrian | - |
dc.contributor.author | Arachchi, Harindra | - |
dc.contributor.author | Asa, Sylvia L. | - |
dc.contributor.author | Auman, J. Todd | - |
dc.contributor.author | Balasundaram, Miruna | - |
dc.contributor.author | Balu, Saianand | - |
dc.contributor.author | Baylin, Stephen B. | - |
dc.contributor.author | Behera, Madhusmita | - |
dc.contributor.author | Bernard, Brady | - |
dc.contributor.author | Beroukhim, Rameen | - |
dc.contributor.author | Bishop, Justin A. | - |
dc.contributor.author | Black, Aaron D. | - |
dc.contributor.author | Bodenheimer, Tom | - |
dc.contributor.author | Boice, Lori | - |
dc.contributor.author | Bootwalla, Moiz S. | - |
dc.contributor.author | Bowen, Jay | - |
dc.contributor.author | Bowlby, Reanne | - |
dc.contributor.author | Bristow, Christopher A. | - |
dc.contributor.author | Brookens, Robin | - |
dc.contributor.author | Brooks, Denise | - |
dc.contributor.author | Bryant, Robert | - |
dc.contributor.author | Buda, Elizabeth | - |
dc.contributor.author | Butterfield, Yaron S. N. | - |
dc.contributor.author | Carling, Tobias | - |
dc.contributor.author | Carlsen, Rebecca | - |
dc.contributor.author | Carter, Scott L. | - |
dc.contributor.author | Carty, Sally E. | - |
dc.contributor.author | Chan, Timothy A. | - |
dc.contributor.author | Chen, Amy Y. | - |
dc.contributor.author | Cherniack, Andrew D. | - |
dc.contributor.author | Cheung, Dorothy | - |
dc.contributor.author | Chin, Lynda | - |
dc.contributor.author | Cho, Juok | - |
dc.contributor.author | Chu, Andy | - |
dc.contributor.author | Chuah, Eric | - |
dc.contributor.author | Cibulskis, Kristian | - |
dc.contributor.author | Ciriello, Giovanni | - |
dc.contributor.author | Clarke, Amanda | - |
dc.contributor.author | Clayman, Gary L. | - |
dc.contributor.author | Cope, Leslie | - |
dc.contributor.author | Copland, John A. | - |
dc.contributor.author | Covington, Kyle | - |
dc.contributor.author | Danilova, Ludmila | - |
dc.contributor.author | Davidsen, Tanja | - |
dc.contributor.author | Demchok, John A. | - |
dc.contributor.author | DiCara, Daniel | - |
dc.contributor.author | Dhalla, Noreen | - |
dc.contributor.author | Dhir, Rajiv | - |
dc.contributor.author | Dookran, Sheliann S. | - |
dc.contributor.author | Dresdner, Gideon | - |
dc.contributor.author | Eldridge, Jonathan | - |
dc.contributor.author | Eley, Greg | - |
dc.contributor.author | El-Naggar, Adel K. | - |
dc.contributor.author | Eng, Stephanie | - |
dc.contributor.author | Fagin, James A. | - |
dc.contributor.author | Fennell, Timothy | - |
dc.contributor.author | Ferris, Robert L. | - |
dc.contributor.author | Fisher, Sheila | - |
dc.contributor.author | Frazer, Scott | - |
dc.contributor.author | Frick, Jessica | - |
dc.contributor.author | Gabriel, Stacey B. | - |
dc.contributor.author | Ganly, Ian | - |
dc.contributor.author | Gao, Jianjiong | - |
dc.contributor.author | Garraway, Levi A. | - |
dc.contributor.author | Gastier-Foster, Julie M. | - |
dc.contributor.author | Getz, Gad | - |
dc.contributor.author | Gehlenborg, Nils | - |
dc.contributor.author | Ghossein, Ronald | - |
dc.contributor.author | Gibbs, Richard A. | - |
dc.contributor.author | Giordano, Thomas J. | - |
dc.contributor.author | Gomez-Hernandez, Karen | - |
dc.contributor.author | Grimsby, Jonna | - |
dc.contributor.author | Gross, Benjamin | - |
dc.contributor.author | Guin, Ranabir | - |
dc.contributor.author | Hadjipanayis, Angela | - |
dc.contributor.author | Harper, Hollie A. | - |
dc.contributor.author | Hayes, D. Neil | - |
dc.contributor.author | Heiman, David I. | - |
dc.contributor.author | Herman, James G. | - |
dc.contributor.author | Hoadley, Katherine A. | - |
dc.contributor.author | Hofree, Matan | - |
dc.contributor.author | Holt, Robert A. | - |
dc.contributor.author | Hoyle, Alan P. | - |
dc.contributor.author | Huang, Franklin W. | - |
dc.contributor.author | Huang, Mei | - |
dc.contributor.author | Hutter, Carolyn M. | - |
dc.contributor.author | Ideker, Trey | - |
dc.contributor.author | Iype, Lisa | - |
dc.contributor.author | Jacobsen, Anders | - |
dc.contributor.author | Jefferys, Stuart R. | - |
dc.contributor.author | Jones, Corbin D. | - |
dc.contributor.author | Jones, Steven J. M. | - |
dc.contributor.author | Kasaian, Katayoon | - |
dc.contributor.author | Kebebew, Electron | - |
dc.contributor.author | Khuri, Fadlo R. | - |
dc.contributor.author | Kim, Jaegil | - |
dc.contributor.author | Kramer, Roger | - |
dc.contributor.author | Kreisberg, Richard | - |
dc.contributor.author | Kucherlapati, Raju | - |
dc.contributor.author | Kwiatkowski, David J. | - |
dc.contributor.author | Ladanyi, Marc | - |
dc.contributor.author | Lai, Phillip H. | - |
dc.contributor.author | Laird, Peter W. | - |
dc.contributor.author | Lander, Eric | - |
dc.contributor.author | Lawrence, Michael S. | - |
dc.contributor.author | Lee, Darlene | - |
dc.contributor.author | Lee, Eunjung | - |
dc.contributor.author | Lee, Semin | - |
dc.contributor.author | Lee, William | - |
dc.contributor.author | Leraas, Kristen M. | - |
dc.contributor.author | Lichtenberg, Tara M. | - |
dc.contributor.author | Lichtenstein, Lee | - |
dc.contributor.author | Lin, Pei | - |
dc.contributor.author | Ling, Shiyun | - |
dc.contributor.author | Liu, Jinze | - |
dc.contributor.author | Liu, Wenbin | - |
dc.contributor.author | Liu, Yingchun | - |
dc.contributor.author | LiVolsi, Virginia A. | - |
dc.contributor.author | Lu, Yiling | - |
dc.contributor.author | Ma, Yussanne | - |
dc.contributor.author | Mahadeshwar, Harshad S. | - |
dc.contributor.author | Marra, Marco A. | - |
dc.contributor.author | Mayo, Michael | - |
dc.contributor.author | McFadden, David G. | - |
dc.contributor.author | Meng, Shaowu | - |
dc.contributor.author | Meyerson, Matthew | - |
dc.contributor.author | Mieczkowski, Piotr A. | - |
dc.contributor.author | Miller, Michael | - |
dc.contributor.author | Mills, Gordon | - |
dc.contributor.author | Moore, Richard A. | - |
dc.contributor.author | Mose, Lisle E. | - |
dc.contributor.author | Mungall, Andrew J. | - |
dc.contributor.author | Murray, Bradley A. | - |
dc.contributor.author | Nikiforov, Yuri E. | - |
dc.contributor.author | Noble, Michael S. | - |
dc.contributor.author | Ojesina, Akinyemi I. | - |
dc.contributor.author | Owonikoko, Taofeek K. | - |
dc.contributor.author | Ozenberger, Bradley A. | - |
dc.contributor.author | Pantazi, Angeliki | - |
dc.contributor.author | Parfenov, Michael | - |
dc.contributor.author | Park, Peter J. | - |
dc.contributor.author | Parker, Joel S. | - |
dc.contributor.author | Paull, Evan O. | - |
dc.contributor.author | Pedamallu, Chandra Sekhar | - |
dc.contributor.author | Perou, Charles M. | - |
dc.contributor.author | Prins, Jan F. | - |
dc.contributor.author | Protopopov, Alexei | - |
dc.contributor.author | Ramalingam, Suresh S. | - |
dc.contributor.author | Ramirez, Nilsa C. | - |
dc.contributor.author | Ramirez, Ricardo | - |
dc.contributor.author | Raphael, Benjamin J. | - |
dc.contributor.author | Rathmell, W. Kimryn | - |
dc.contributor.author | Ren, Xiaojia | - |
dc.contributor.author | Reynolds, Sheila M. | - |
dc.contributor.author | Rheinbay, Esther | - |
dc.contributor.author | Ringel, Matthew D. | - |
dc.contributor.author | Rivera, Michael | - |
dc.contributor.author | Roach, Jeffrey | - |
dc.contributor.author | Robertson, A. Gordon | - |
dc.contributor.author | Rosenberg, Mara W. | - |
dc.contributor.author | Rosenthal, Matthew | - |
dc.contributor.author | Sadeghi, Sara | - |
dc.contributor.author | Saksena, Gordon | - |
dc.contributor.author | Sander, Chris | - |
dc.contributor.author | Santoso, Netty | - |
dc.contributor.author | Schein, Jacqueline E. | - |
dc.contributor.author | Schultz, Nikolaus | - |
dc.contributor.author | Schumacher, Steven E. | - |
dc.contributor.author | Seethala, Raja R. | - |
dc.contributor.author | Seidman, Jonathan | - |
dc.contributor.author | Senbabaoglu, Yasin | - |
dc.contributor.author | Seth, Sahil | - |
dc.contributor.author | Sharpe, Samantha | - |
dc.contributor.author | Shaw, Kenna R. Mills | - |
dc.contributor.author | Shen, John P. | - |
dc.contributor.author | Shen, Ronglai | - |
dc.contributor.author | Sherman, Steven | - |
dc.contributor.author | Sheth, Margi | - |
dc.contributor.author | Shi, Yan | - |
dc.contributor.author | Shmulevich, Ilya | - |
dc.contributor.author | Sica, Gabriel L. | - |
dc.contributor.author | Simons, Janae V. | - |
dc.contributor.author | Sinha, Rileen | - |
dc.contributor.author | Sipahimalani, Payal | - |
dc.contributor.author | Smallridge, Robert C. | - |
dc.contributor.author | Sofia, Heidi J. | - |
dc.contributor.author | Soloway, Matthew G. | - |
dc.contributor.author | Song, Xingzhi | - |
dc.contributor.author | Sougnez, Carrie | - |
dc.contributor.author | Stewart, Chip | - |
dc.contributor.author | Stojanov, Petar | - |
dc.contributor.author | Stuart, Joshua M. | - |
dc.contributor.author | Sumer, S. Onur | - |
dc.contributor.author | Sun, Yichao | - |
dc.contributor.author | Tabak, Barbara | - |
dc.contributor.author | Tam, Angela | - |
dc.contributor.author | Tan, Donghui | - |
dc.contributor.author | Tang, Jiabin | - |
dc.contributor.author | Tarnuzzer, Roy | - |
dc.contributor.author | Taylor, Barry S. | - |
dc.contributor.author | Thiessen, Nina | - |
dc.contributor.author | Thorne, Leigh | - |
dc.contributor.author | Thorsson, Vesteinn | - |
dc.contributor.author | Tuttle, R. Michael | - |
dc.contributor.author | Umbricht, Christopher B. | - |
dc.contributor.author | Van Den Berg, David J. | - |
dc.contributor.author | Vandin, Fabio | - |
dc.contributor.author | Veluvolu, Umadevi | - |
dc.contributor.author | Verhaak, Roel G. W. | - |
dc.contributor.author | Vinco, Michelle | - |
dc.contributor.author | Voet, Doug | - |
dc.contributor.author | Walter, Vonn | - |
dc.contributor.author | Wang, Zhining | - |
dc.contributor.author | Waring, Scot | - |
dc.contributor.author | Weinberger, Paul M. | - |
dc.contributor.author | Weinhold, Nils | - |
dc.contributor.author | Weinstein, John N. | - |
dc.contributor.author | Weisenberger, Daniel J. | - |
dc.contributor.author | Wheeler, David | - |
dc.contributor.author | Wilkerson, Matthew D. | - |
dc.contributor.author | Wilson, Jocelyn | - |
dc.contributor.author | Williams, Michelle | - |
dc.contributor.author | Winer, Daniel A. | - |
dc.contributor.author | Wise, Lisa | - |
dc.contributor.author | Wu, Junyuan | - |
dc.contributor.author | Xi, Liu | - |
dc.contributor.author | Xu, Andrew W. | - |
dc.contributor.author | Yang, Liming | - |
dc.contributor.author | Yang, Lixing | - |
dc.contributor.author | Zack, Travis I. | - |
dc.contributor.author | Zeiger, Martha A. | - |
dc.contributor.author | Zeng, Dong | - |
dc.contributor.author | Zenklusen, Jean Claude | - |
dc.contributor.author | Zhao, Ni | - |
dc.contributor.author | Zhang, Hailei | - |
dc.contributor.author | Zhang, Jianhua | - |
dc.contributor.author | Zhang, Jiashan (Julia) | - |
dc.contributor.author | Zhang, Wei | - |
dc.contributor.author | Zmuda, Erik | - |
dc.contributor.author | Zou, Lihua | - |
dc.date.accessioned | 2023-12-22T02:08:23Z | - |
dc.date.available | 2023-12-22T02:08:23Z | - |
dc.date.created | 2016-03-28 | - |
dc.date.issued | 2014-10 | - |
dc.description.abstract | Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Here, we describe the genomic landscape of 496 PTCs. We observed a low frequency of somatic alterations (relative to other carcinomas) and extended the set of known PTC driver alterations to include EIF1AX, PPM1D, and CHEK2 and diverse gene fusions. These discoveries reduced the fraction of PTC cases with unknown oncogenic driver from 25% to 3.5%. Combined analyses of genomic variants, gene expression, and methylation demonstrated that different driver groups lead to different pathologies with distinct signaling and differentiation characteristics. Similarly, we identified distinct molecular subgroups of BRAF-mutant tumors, and multidimensional analyses highlighted a potential involvement of onco-miRs in less-differentiated subgroups. Our results propose a reclassification of thyroid cancers into molecular subtypes that better reflect their underlying signaling and differentiation properties, which has the potential to improve their pathological classification and better inform the management of the disease | - |
dc.identifier.bibliographicCitation | CELL, v.159, no.3, pp.676 - 690 | - |
dc.identifier.doi | 10.1016/j.cell.2014.09.050 | - |
dc.identifier.issn | 0092-8674 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/18878 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0092867414012380 | - |
dc.identifier.wosid | 000344521700021 | - |
dc.language | 영어 | - |
dc.publisher | CELL PRESS | - |
dc.title | Integrated Genomic Characterization of Papillary Thyroid Carcinoma | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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