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DC Field | Value | Language |
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dc.citation.endPage | 1025 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1011 | - |
dc.citation.title | CELL | - |
dc.citation.volume | 163 | - |
dc.contributor.author | Abeshouse, Adam | - |
dc.contributor.author | Ahn, Jaeil | - |
dc.contributor.author | Akbani, Rehan | - |
dc.contributor.author | Ally, Adrian | - |
dc.contributor.author | Amin, Samirkumar | - |
dc.contributor.author | Andry, Christopher D. | - |
dc.contributor.author | Annala, Matti | - |
dc.contributor.author | Aprikian, Armen | - |
dc.contributor.author | Armenia, Joshua | - |
dc.contributor.author | Arora, Arshi | - |
dc.contributor.author | Auman, J. Todd | - |
dc.contributor.author | Balasundaram, Miruna | - |
dc.contributor.author | Balu, Saianand | - |
dc.contributor.author | Barbieri, Christopher E. | - |
dc.contributor.author | Bauer, Thomas | - |
dc.contributor.author | Benz, Christopher C. | - |
dc.contributor.author | Bergeron, Alain | - |
dc.contributor.author | Beroukhim, Rameen | - |
dc.contributor.author | Berrios, Mario | - |
dc.contributor.author | Bivol, Adrian | - |
dc.contributor.author | Bodenheimer, Tom | - |
dc.contributor.author | Boice, Lori | - |
dc.contributor.author | Bootwalla, Moiz S. | - |
dc.contributor.author | dos Reis, Rodolfo Borges | - |
dc.contributor.author | Boutros, Paul C. | - |
dc.contributor.author | Bowen, Jay | - |
dc.contributor.author | Bowlby, Reanne | - |
dc.contributor.author | Boyd, Jeffrey | - |
dc.contributor.author | Bradley, Robert K. | - |
dc.contributor.author | Breggia, Anne | - |
dc.contributor.author | Brimo, Fadi | - |
dc.contributor.author | Bristow, Christopher A. | - |
dc.contributor.author | Brooks, Denise | - |
dc.contributor.author | Broom, Bradley M. | - |
dc.contributor.author | Bryce, Alan H. | - |
dc.contributor.author | Bubley, Glenn | - |
dc.contributor.author | Burks, Eric | - |
dc.contributor.author | Butterfield, Yaron S. N. | - |
dc.contributor.author | Button, Michael | - |
dc.contributor.author | Canes, David | - |
dc.contributor.author | Carlotti, Carlos G. | - |
dc.contributor.author | Carlsen, Rebecca | - |
dc.contributor.author | Carmel, Michel | - |
dc.contributor.author | Carroll, Peter R. | - |
dc.contributor.author | Carter, Scott L. | - |
dc.contributor.author | Cartun, Richard | - |
dc.contributor.author | Carver, Brett S. | - |
dc.contributor.author | Chan, June M. | - |
dc.contributor.author | Chang, Matthew T. | - |
dc.contributor.author | Chen, Yu | - |
dc.contributor.author | Cherniack, Andrew D. | - |
dc.contributor.author | Chevalier, Simone | - |
dc.contributor.author | Chin, Lynda | - |
dc.contributor.author | Cho, Juok | - |
dc.contributor.author | Chu, Andy | - |
dc.contributor.author | Chuah, Eric | - |
dc.contributor.author | Chudamani, Sudha | - |
dc.contributor.author | Cibulskis, Kristian | - |
dc.contributor.author | Ciriello, Giovanni | - |
dc.contributor.author | Clarke, Amanda | - |
dc.contributor.author | Cooperberg, Matthew R. | - |
dc.contributor.author | Corcoran, Niall M. | - |
dc.contributor.author | Costello, Anthony J. | - |
dc.contributor.author | Cowan, Janet | - |
dc.contributor.author | Crain, Daniel | - |
dc.contributor.author | Curley, Erin | - |
dc.contributor.author | David, Kerstin | - |
dc.contributor.author | Demchok, John A. | - |
dc.contributor.author | Demichelis, Francesca | - |
dc.contributor.author | Dhalla, Noreen | - |
dc.contributor.author | Dhir, Rajiv | - |
dc.contributor.author | Doueik, Alexandre | - |
dc.contributor.author | Drake, Bettina | - |
dc.contributor.author | Dvinge, Heidi | - |
dc.contributor.author | Dyakova, Natalya | - |
dc.contributor.author | Felau, Ina | - |
dc.contributor.author | Ferguson, Martin L. | - |
dc.contributor.author | Frazer, Scott | - |
dc.contributor.author | Freedland, Stephen | - |
dc.contributor.author | Fu, Yao | - |
dc.contributor.author | Gabriel, Stacey B. | - |
dc.contributor.author | Gao, Jianjiong | - |
dc.contributor.author | Gardner, Johanna | - |
dc.contributor.author | Gastier-Foster, Julie M. | - |
dc.contributor.author | Gehlenborg, Nils | - |
dc.contributor.author | Gerken, Mark | - |
dc.contributor.author | Gerstein, Mark B. | - |
dc.contributor.author | Getz, Gad | - |
dc.contributor.author | Godwin, Andrew K. | - |
dc.contributor.author | Gopalan, Anuradha | - |
dc.contributor.author | Graefen, Markus | - |
dc.contributor.author | Graim, Kiley | - |
dc.contributor.author | Gribbin, Thomas | - |
dc.contributor.author | Guin, Ranabir | - |
dc.contributor.author | Gupta, Manaswi | - |
dc.contributor.author | Hadjipanayis, Angela | - |
dc.contributor.author | Haider, Syed | - |
dc.contributor.author | Hamel, Lucie | - |
dc.contributor.author | Hayes, D. Neil | - |
dc.contributor.author | Heiman, David I. | - |
dc.contributor.author | Hess, Julian | - |
dc.contributor.author | Hoadley, Katherine A. | - |
dc.contributor.author | Holbrook, Andrea H. | - |
dc.contributor.author | Holt, Robert A. | - |
dc.contributor.author | Holway, Antonia | - |
dc.contributor.author | Hovens, Christopher M. | - |
dc.contributor.author | Hoyle, Alan P. | - |
dc.contributor.author | Huang, Mei | - |
dc.contributor.author | Hutter, Carolyn M. | - |
dc.contributor.author | Ittmann, Michael | - |
dc.contributor.author | Iype, Lisa | - |
dc.contributor.author | Jefferys, Stuart R. | - |
dc.contributor.author | Jones, Corbin D. | - |
dc.contributor.author | Jones, Steven J. M. | - |
dc.contributor.author | Juhl, Hartmut | - |
dc.contributor.author | Kahles, Andre | - |
dc.contributor.author | Kane, Christopher J. | - |
dc.contributor.author | Kasaian, Katayoon | - |
dc.contributor.author | Kerger, Michael | - |
dc.contributor.author | Khurana, Ekta | - |
dc.contributor.author | Kim, Jaegil | - |
dc.contributor.author | Klein, Robert J. | - |
dc.contributor.author | Kucherlapati, Raju | - |
dc.contributor.author | Lacombe, Louis | - |
dc.contributor.author | Ladanyi, Marc | - |
dc.contributor.author | Lai, Phillip H. | - |
dc.contributor.author | Laird, Peter W. | - |
dc.contributor.author | Lander, Eric S. | - |
dc.contributor.author | Latour, Mathieu | - |
dc.contributor.author | Lawrence, Michael S. | - |
dc.contributor.author | Lau, Kevin | - |
dc.contributor.author | LeBien, Tucker | - |
dc.contributor.author | Lee, Darlene | - |
dc.contributor.author | Lee, Semin | - |
dc.contributor.author | Lehmann, Kjong-Van | - |
dc.contributor.author | Leraas, Kristen M. | - |
dc.contributor.author | Leshchiner, Ignaty | - |
dc.contributor.author | Leung, Robert | - |
dc.contributor.author | Libertino, John A. | - |
dc.contributor.author | Lichtenberg, Tara M. | - |
dc.contributor.author | Lin, Pei | - |
dc.contributor.author | Linehan, W. Marston | - |
dc.contributor.author | Ling, Shiyun | - |
dc.contributor.author | Lippman, Scott M. | - |
dc.contributor.author | Liu, Jia | - |
dc.contributor.author | Liu, Wenbin | - |
dc.contributor.author | Lochovsky, Lucas | - |
dc.contributor.author | Loda, Massimo | - |
dc.contributor.author | Logothetis, Christopher | - |
dc.contributor.author | Lolla, Laxmi | - |
dc.contributor.author | Longacre, Teri | - |
dc.contributor.author | Lu, Yiling | - |
dc.contributor.author | Luo, Jianhua | - |
dc.contributor.author | Ma, Yussanne | - |
dc.contributor.author | Mahadeshwar, Harshad S. | - |
dc.contributor.author | Mallery, David | - |
dc.contributor.author | Mariamidze, Armaz | - |
dc.contributor.author | Marra, Marco A. | - |
dc.contributor.author | Mayo, Michael | - |
dc.contributor.author | McCall, Shannon | - |
dc.contributor.author | McKercher, Ginette | - |
dc.contributor.author | Meng, Shaowu | - |
dc.contributor.author | Mes-Masson, Anne-Marie | - |
dc.contributor.author | Merino, Maria J. | - |
dc.contributor.author | Meyersson, Matthew | - |
dc.contributor.author | Mieczkowski, Piotr A. | - |
dc.contributor.author | Mills, Gordon B. | - |
dc.contributor.author | Shaw, Kenna R. Mills | - |
dc.contributor.author | Minner, Sarah | - |
dc.contributor.author | Moinzadeh, Alireza | - |
dc.contributor.author | Moore, Richard A. | - |
dc.contributor.author | Morris, Scott | - |
dc.contributor.author | Morrison, Carl | - |
dc.contributor.author | Mose, Lisle E. | - |
dc.contributor.author | Mungall, Andrew J. | - |
dc.contributor.author | Murray, Bradley A. | - |
dc.contributor.author | Myers, Jerome B. | - |
dc.contributor.author | Naresh, Rashi | - |
dc.contributor.author | Nelson, Joel | - |
dc.contributor.author | Nelson, Mark A. | - |
dc.contributor.author | Nelson, Peter S. | - |
dc.contributor.author | Newton, Yulia | - |
dc.contributor.author | Noble, Michael S. | - |
dc.contributor.author | Noushmehr, Houtan | - |
dc.contributor.author | Nykter, Matti | - |
dc.contributor.author | Pantazi, Angeliki | - |
dc.contributor.author | Parfenov, Michael | - |
dc.contributor.author | Park, Peter J. | - |
dc.contributor.author | Parker, Joel S. | - |
dc.contributor.author | Paulauskis, Joseph | - |
dc.contributor.author | Penny, Robert | - |
dc.contributor.author | Perou, Charles M. | - |
dc.contributor.author | Piche, Alain | - |
dc.contributor.author | Pihl, Todd | - |
dc.contributor.author | Pinto, Peter A. | - |
dc.contributor.author | Prandi, Davide | - |
dc.contributor.author | Protopopov, Alexei | - |
dc.contributor.author | Ramirez, Nilsa C. | - |
dc.contributor.author | Rao, Arvind | - |
dc.contributor.author | Rathmell, W. Kimryn | - |
dc.contributor.author | Raetsch, Gunnar | - |
dc.contributor.author | Ren, Xiaojia | - |
dc.contributor.author | Reuter, Victor E. | - |
dc.contributor.author | Reynolds, Sheila M. | - |
dc.contributor.author | Rhie, Suhn K. | - |
dc.contributor.author | Rieger-Christ, Kimberly | - |
dc.contributor.author | Roach, Jeffrey | - |
dc.contributor.author | Robertson, A. Gordon | - |
dc.contributor.author | Robinson, Brian | - |
dc.contributor.author | Rubin, Mark A. | - |
dc.contributor.author | Saad, Fred | - |
dc.contributor.author | Sadeghi, Sara | - |
dc.contributor.author | Saksena, Gordon | - |
dc.contributor.author | Saller, Charles | - |
dc.contributor.author | Salner, Andrew | - |
dc.contributor.author | Sanchez-Vega, Francisco | - |
dc.contributor.author | Sander, Chris | - |
dc.contributor.author | Sandusky, George | - |
dc.contributor.author | Sauter, Guido | - |
dc.contributor.author | Sboner, Andrea | - |
dc.contributor.author | Scardino, Peter T. | - |
dc.contributor.author | Scarlata, Eleonora | - |
dc.contributor.author | Schein, Jacqueline E. | - |
dc.contributor.author | Schlomm, Thorsten | - |
dc.contributor.author | Schmidt, Laura S. | - |
dc.contributor.author | Schultz, Nikolaus | - |
dc.contributor.author | Schumacher, Steven E. | - |
dc.contributor.author | Seidman, Jonathan | - |
dc.contributor.author | Neder, Luciano | - |
dc.contributor.author | Seth, Sahil | - |
dc.contributor.author | Sharp, Alexis | - |
dc.contributor.author | Shelton, Candace | - |
dc.contributor.author | Shelton, Troy | - |
dc.contributor.author | Shen, Hui | - |
dc.contributor.author | Shen, Ronglai | - |
dc.contributor.author | Sherman, Mark | - |
dc.contributor.author | Sheth, Margi | - |
dc.contributor.author | Shi, Yan | - |
dc.contributor.author | Shih, Juliann | - |
dc.contributor.author | Shmulevich, Ilya | - |
dc.contributor.author | Simko, Jeffry | - |
dc.contributor.author | Simon, Ronald | - |
dc.contributor.author | Simons, Janae V. | - |
dc.contributor.author | Sipahimalani, Payal | - |
dc.contributor.author | Skelly, Tara | - |
dc.contributor.author | Sofia, Heidi J. | - |
dc.contributor.author | Soloway, Matthew G. | - |
dc.contributor.author | Song, Xingzhi | - |
dc.contributor.author | Sorcini, Andrea | - |
dc.contributor.author | Sougnez, Carrie | - |
dc.contributor.author | Stepa, Serghei | - |
dc.contributor.author | Stewart, Chip | - |
dc.contributor.author | Stewart, John | - |
dc.contributor.author | Stuart, Joshua M. | - |
dc.contributor.author | Sullivan, Travis B. | - |
dc.contributor.author | Sun, Charlie | - |
dc.contributor.author | Sun, Huandong | - |
dc.contributor.author | Tam, Angela | - |
dc.contributor.author | Tan, Donghui | - |
dc.contributor.author | Tang, Jiabin | - |
dc.contributor.author | Tarnuzzer, Roy | - |
dc.contributor.author | Tarvin, Katherine | - |
dc.contributor.author | Taylor, Barry S. | - |
dc.contributor.author | Teebagy, Patrick | - |
dc.contributor.author | Tenggara, Imelda | - |
dc.contributor.author | Tetu, Bernard | - |
dc.contributor.author | Tewari, Ashutosh | - |
dc.contributor.author | Thiessen, Nina | - |
dc.contributor.author | Thompson, Timothy | - |
dc.contributor.author | Thorne, Leigh B. | - |
dc.contributor.author | Tirapelli, Daniela P. | - |
dc.contributor.author | Tomlins, Scott A. | - |
dc.contributor.author | Trevisan, Felipe Amstalden | - |
dc.contributor.author | Troncoso, Patricia | - |
dc.contributor.author | True, Lawrence D. | - |
dc.contributor.author | Tsourlakis, Maria Christina | - |
dc.contributor.author | Tyekucheva, Svitlana | - |
dc.contributor.author | Van Allen, Eliezer | - |
dc.contributor.author | Van den Berg, David J. | - |
dc.contributor.author | Veluvolu, Umadevi | - |
dc.contributor.author | Verhaak, Roel | - |
dc.contributor.author | Vocke, Cathy D. | - |
dc.contributor.author | Voet, Doug | - |
dc.contributor.author | Wan, Yunhu | - |
dc.contributor.author | Wang, Qingguo | - |
dc.contributor.author | Wang, Wenyi | - |
dc.contributor.author | Wang, Zhining | - |
dc.contributor.author | Weinhold, Nils | - |
dc.contributor.author | Weinstein, John N. | - |
dc.contributor.author | Weisenberger, Daniel J. | - |
dc.contributor.author | Wilkerson, Matthew D. | - |
dc.contributor.author | Wise, Lisa | - |
dc.contributor.author | Witte, John | - |
dc.contributor.author | Wu, Chia-Chin | - |
dc.contributor.author | Wu, Junyuan | - |
dc.contributor.author | Wu, Ye | - |
dc.contributor.author | Xu, Andrew W. | - |
dc.contributor.author | Yadav, Shalini S. | - |
dc.contributor.author | Yang, Liming | - |
dc.contributor.author | Yang, Lixing | - |
dc.contributor.author | Yau, Christina | - |
dc.contributor.author | Ye, Huihui | - |
dc.contributor.author | Yena, Peggy | - |
dc.contributor.author | Zeng, Thomas | - |
dc.contributor.author | Zenklusen, Jean C. | - |
dc.contributor.author | Zhang, Hailei | - |
dc.contributor.author | Zhang, Jianhua | - |
dc.contributor.author | Zhang, Jiashan | - |
dc.contributor.author | Zhang, Wei | - |
dc.contributor.author | Zhong, Yi | - |
dc.contributor.author | Zhu, Kelsey | - |
dc.contributor.author | Zmuda, Erik | - |
dc.date.accessioned | 2023-12-22T00:36:54Z | - |
dc.date.available | 2023-12-22T00:36:54Z | - |
dc.date.created | 2016-03-23 | - |
dc.date.issued | 2015-11 | - |
dc.description.abstract | There is substantial heterogeneity among primary prostate cancers, evident in the spectrum of molecular abnormalities and its variable clinical course. As part of The Cancer Genome Atlas (TCGA), we present a comprehensive molecular analysis of 333 primary prostate carcinomas. Our results revealed a molecular taxonomy in which 74% of these tumors fell into one of seven subtypes defined by specific gene fusions (ERG, ETV1/4, and FLI1) or mutations (SPOP, FOXA1, and IDH1). Epigenetic profiles showed substantial heterogeneity, including an IDH1 mutant subset with a methylator phenotype. Androgen receptor (AR) activity varied widely and in a subtype-specific manner, with SPOP and FOXA1 mutant tumors having the highest levels of AR-induced transcripts. 25% of the prostate cancers had a presumed actionable lesion in the PI3K or MAPK signaling pathways, and DNA repair genes were inactivated in 19%. Our analysis reveals molecular heterogeneity among primary prostate cancers, as well as potentially actionable molecular defects | - |
dc.identifier.bibliographicCitation | CELL, v.163, no.4, pp.1011 - 1025 | - |
dc.identifier.doi | 10.1016/j.cell.2015.10.025 | - |
dc.identifier.issn | 0092-8674 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/18785 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0092867415013392 | - |
dc.identifier.wosid | 000364829700024 | - |
dc.language | 영어 | - |
dc.publisher | CELL PRESS | - |
dc.title | The Molecular Taxonomy of Primary Prostate Cancer | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | ETS GENE FUSIONS | - |
dc.subject.keywordPlus | ACTIVE ANDROGEN RECEPTOR | - |
dc.subject.keywordPlus | DNA METHYLATION | - |
dc.subject.keywordPlus | RADICAL PROSTATECTOMY | - |
dc.subject.keywordPlus | GENOMIC ABERRATIONS | - |
dc.subject.keywordPlus | EXPRESSION PROFILES | - |
dc.subject.keywordPlus | WHOLE-GENOME | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.subject.keywordPlus | SPOP | - |
dc.subject.keywordPlus | RECURRENCE | - |
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