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Ryu, Ja-Hyoung
Supramolecular NanoMaterials Lab (SUN)
Research Interests
  • Supramolecular assembly, synthetic peptide assembly, cancer drug delivery

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Glycoconjugate Nanoribbons from Self-Assembly of Carbohydrate-Peptide Block Molecules for Controllable Bacterial Cell Cluster Formation

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Title
Glycoconjugate Nanoribbons from Self-Assembly of Carbohydrate-Peptide Block Molecules for Controllable Bacterial Cell Cluster Formation
Author
Lim, Yong-beomPark, SomiLee, EunjiJeong, HaemiRyu, Ja-HyoungLee, MSLee, Myongsoo
Issue Date
2007-05
Publisher
AMER CHEMICAL SOC
Citation
BIOMACROMOLECULES, v.8, no.5, pp.1404 - 1408
Abstract
We demonstrate here the rational design strategy to control the length of 1-dimensional β-sheet peptide nanoassembly. We synthesized the β-sheet peptides with attached coils and carbohydrates. We reasoned that the bulkiness of the coils affects the final length of the assembled β-sheet peptide nanostructures because of the steric crowding effect. The nanostructure from the peptide with a small and linear coil was several micrometers long, whereas the one from the peptide with a high-volume-fraction dendritic coil was only about 150 nm long. For potential biological applications of the peptide nanoassemblies, we investigated the interactions of the carbohydrate-coated nanoassemblies with E. coli cells containing cognate binding proteins. The results showed that both of the nanoassemblies could immobilize and/or aggregate bacterial cells. The degrees of immobilization were similar for both nanoassemblies; however, only the long nanoribbon was shown to induce the formation of bacterial clusters.
URI
https://scholarworks.unist.ac.kr/handle/201301/18076
URL
http://pubs.acs.org/doi/abs/10.1021/bm0700901
DOI
10.1021/bm0700901
ISSN
1525-7797
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