Guest molecules in a metal-organic framework (MOF), [Zn4O(CPMA)3]·6DMF (DMF = N,N-dimethylformamide), with an interpenetrating pcu net were exchanged with benzene, n-hexane, and methanol in a single-crystal to single-crystal (SC-SC) manner, which involved the sliding motion of the interpenetrating network, as well as the dynamic movements of the molecular components, and was triggered by host-guest interactions.