Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.startPage | 15656 | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 5 | - |
dc.contributor.author | Song, YoungKyu | - |
dc.contributor.author | Kang, Young Ji | - |
dc.contributor.author | Jung, Hoesu | - |
dc.contributor.author | Kim, Hansol | - |
dc.contributor.author | Kang, Sebyung | - |
dc.contributor.author | Cho, Hyungjoon | - |
dc.date.accessioned | 2023-12-22T00:39:58Z | - |
dc.date.available | 2023-12-22T00:39:58Z | - |
dc.date.created | 2015-11-04 | - |
dc.date.issued | 2015-10 | - |
dc.description.abstract | With the applications of magnetic resonance imaging (MRI) at higher magnetic fields increasing, there is demand for MRI contrast agents with improved relaxivity at higher magnetic fields. Macromolecule-based contrast agents, such as protein-based ones, are known to yield significantly higher r(1) relaxivity at low fields, but tend to lose this merit when used as T-1 contrast agents (r(1)/r(2) = 0.5 similar to 1), with their r(1) decreasing and r(2) increasing as magnetic field strength increases. Here, we developed and characterized an in vivo applicable magnetic resonance (MR) positive contrast agent by conjugating Gd(III)-chelating agent complexes to lumazine synthase isolated from Aquifex aeolicus (AaLS). The r(1) relaxivity of Gd(III)-DOTA-AaLS-R108C was 16.49 mM(-1)s(-1) and its r(1)/r(2) ratio was 0.52 at the magnetic field strength of 7 T. The results of 3D MR angiography demonstrated the feasibility of vasculature imaging within 2 h of intravenous injection of the agent and a significant reduction in T-1 values were observed in the tumor region 7 h post-injection in the SCC-7 flank tumor model. Our findings suggest that Gd(III)-DOTA-AaLS-R108C could serve as a potential theranostic nanoplatform at high magnetic field strength. | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.5, pp.15656 | - |
dc.identifier.doi | 10.1038/srep15656 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.scopusid | 2-s2.0-84944909319 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/17696 | - |
dc.identifier.url | http://www.nature.com/articles/srep15656 | - |
dc.identifier.wosid | 000363427300001 | - |
dc.language | 영어 | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Lumazine Synthase Protein Nanoparticle-Gd(III)-DOTA Conjugate as a T1 contrast agent for high-field MRI | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | TRANSFER RADICAL POLYMERIZATION | - |
dc.subject.keywordPlus | TARGETED DRUG-DELIVERY | - |
dc.subject.keywordPlus | CAGE NANOPARTICLES | - |
dc.subject.keywordPlus | GADOLINIUM COMPLEX | - |
dc.subject.keywordPlus | AQUIFEX-AEOLICUS | - |
dc.subject.keywordPlus | VIRAL CAPSIDS | - |
dc.subject.keywordPlus | MOSAIC-VIRUS | - |
dc.subject.keywordPlus | CANCER-CELLS | - |
dc.subject.keywordPlus | IRON-OXIDE | - |
dc.subject.keywordPlus | RELAXIVITY | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.