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Lim, Chunghun
Neurogenetics & Ribonomics Laboratory (The Lim Lab)
Research Interests
  • Post-transcriptional Gene Expression, Neurodegeneration, Behavioral Genetics

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Warming Up Your Tick-Tock: Temperature-Dependent Regulation of Circadian Clocks

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Title
Warming Up Your Tick-Tock: Temperature-Dependent Regulation of Circadian Clocks
Author
Ki, YoonheeRi, HwajungLee, HoyeonYoo, EunseokChoe, JoonhoLim, Chunghun
Issue Date
2015-10
Publisher
SAGE PUBLICATIONS INC
Citation
NEUROSCIENTIST, v.21, no.5, pp.503 - 518
Abstract
Circadian clocks are endogenous time-keeping mechanisms to adaptively coordinate animal behaviors and physiology with daily environmental changes. So far many circadian studies in model organisms have identified evolutionarily conserved molecular frames of circadian clock genes in the context of transcription-translation feedback loops. The molecular clockwork drives cell-autonomously cycling gene expression with similar to 24-hour periodicity, which is fundamental to circadian rhythms. Light and temperature are two of the most potent external time cues to reset the circadian phase of the internal clocks, yet relatively little is known about temperature-relevant clock regulation. In this review, we describe recent findings on temperature-dependent clock mechanisms in homeothermic mammals as compared with poikilothermic Drosophila at molecular, neural, and organismal levels. We propose thermodynamic transitions in RNA secondary structures might have been potent substrates for the molecular evolution of temperature-relevant post-transcriptional mechanisms. Future works should thus validate the potential involvement of specific post-transcriptional steps in temperature-dependent plasticity of circadian clocks.
URI
https://scholarworks.unist.ac.kr/handle/201301/16924
URL
http://nro.sagepub.com/content/21/5/503.long
DOI
10.1177/1073858415577083
ISSN
1073-8584
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