Highly Sensitive and Selective Biosensors Based on Organic Transistors Functionalized with Cucurbituril Derivatives
Cited 0 times inCited 0 times in
- Highly Sensitive and Selective Biosensors Based on Organic Transistors Functionalized with Cucurbituril Derivatives
- Jang, Moonjeong; Kim, Hyoeun; Lee, Sunri; Kim, Hyun Woo; Khedkar, Jayshree K.; Rhee, Young Min; Hwang , Ilha; Kim, Kimoon; Oh, Joon Hak
- Issue Date
- WILEY-V C H VERLAG GMBH
- ADVANCED FUNCTIONAL MATERIALS, v.25, no.30, pp.4882 - 4888
- Biosensors based on a field-effect transistor platform allow continuous monitoring of biologically active species with high sensitivity due to the amplification capability of detected signals. To date, a large number of sensors for biogenic substances have used high-cost enzyme immobilization methods. Here, highly sensitive organic field-effect transistor (OFET)-based sensors functionalized with synthetic receptors are reported that can selectively detect acetylcholine (ACh(+)), a critical ion related to the delivery of neural stimulation. A cucurbituril (CB) derivative, perallyloxyCB ((allyloxy)(12)CB, AOCB), which is soluble in methanol but insoluble in water, has been solution-deposited as a selective sensing layer onto a water-stable p-channel semiconductor, 5,5-bis-(7-dodecyl-9H-fluoren-2-yl)-2,2-bithiophene layer. The OFET-based sensors exhibit a detection limit down to 1 x 10(-12) m of ACh(+), which is six orders of magnitude lower than that of ion-selective electrode-based sensors. Moreover, these OFET-based sensors show highly selective discrimination of ACh(+) over choline (Ch(+)). The findings demonstrate a viable method for the fabrication of OFET-based biosensors with high sensitivity and selectivity, and allow for practical applications of OFETs as high-performance sensors for biogenic substances.
- Appears in Collections:
- ETC_Journal Papers
- Files in This Item:
- There are no files associated with this item.
can give you direct access to the published full text of this article. (UNISTARs only)
Show full item record
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.