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Bhak, Jong
KOrean GenomIcs Center(KOGIC)
Research Interests
  • Geromics, genomics, bioinformatics, protein Engineering, OMICS

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Identification of Close Relatives in the HUGO Pan-Asian SNP Database

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Title
Identification of Close Relatives in the HUGO Pan-Asian SNP Database
Author
Yang, XiongXu, ShuhuaBhak, Jong hwaAbdulla, Mahmood AmeenAhmed, IkhlakAssawamakin, AnunchaiBrahmachari, Samir K.Calacal, Gayvelline C.Chaurasia, AChen, Chien-HsiunChen, JiemingChen, Yuan-TsongChu, Jiayoude la Paz, Eva Maria C. CutiongcoUngria, Maria Corazon A. DeDelfin, Frederick C.Edo, JuliFuchareon, SuthatGhang, HoGojobori, TakashiHan, JunsongHo, Sheng-FengHoh, Boon PengHuang, WeiInoko, HidetoshiJha, PankajJinam, Timothy A.Jin, LiJung, JongsunKangwanpong, DaoroongKampuansai, JatupolKennedy, Giulia C.Khurana, PreetiKim, Hyung-LaeKim, KwangjoongKim, SangsooKim, Woo-YeonKimm, KuchanKimura, RyosukeKoike, TomohiroKulawonganunchai, SupasakKumar, VikrantLai, Poh SanLee, Jong-YoungLee, SunghoonLiu, Edison T.Majumder, Partha P.Mandapati, Miran KumarMarzuki, SangkotMitchell, WayneMukerji, MitaliNaritomi, KenjiNgamphiw, ChumpolNiikawa, NorioNishida, NaoOh, BermseokOh, SanghoOhashi, JunOka, AkiraOng, RickPadilla, Carmencita D.Palittapongarnpim, PrasitPerdigon, Henry B.Phipps, Maude ElviraPng, EileenSakaki, YoshiyukiSalvador, Jazelyn M.Sandraling, YulianaScaria, VinodSeielstad, MarkSidek, Mohd RosSinha, AmitSrikummool, MetaweeSudoyo, HerawatiSugano, SumioSuryadi, HelenaSuzuki, YoshiyokiTabbada, Kristina A.Tan, AdrianTokunaga, KatsushiTongsima, SissadesVillamor, Lilian P.Wang, EricWang, YingWang, HaifengWu, Jer-YuarnXiao, HuashengXu, SYang, Jin OkShugart, Yin YaoYoo, Hyang-SookYuan, WentaoZhao, GuopingZilfalil, Bin Alwi
Keywords
Asian; China; chromosome analysis; controlled study; female; genetic database; genotype; human; India; Indonesia; Japan; Malaysia; male; molecular phylogeny; monozygotic twins; Philippines; population genetics; relative; sex difference; Singapore; single nucleotide polymorphism; South Korea; Taiwan; Thailand; X chromosome; Asian; family; genetic database; genetics; human genome; pedigree; population genetics
Issue Date
2011-12
Publisher
PUBLIC LIBRARY SCIENCE
Citation
PLOS ONE, v.6, no.12, pp. -
Abstract
The HUGO Pan-Asian SNP Consortium has recently released a genome-wide dataset, which consists of 1,719 DNA samples collected from 71 Asian populations. For studies of human population genetics such as genetic structure and migration history, this provided the most comprehensive large-scale survey of genetic variation to date in East and Southeast Asia. However, although considered in the analysis, close relatives were not clearly reported in the original paper. Here we performed a systematic analysis of genetic relationships among individuals from the Pan-Asian SNP (PASNP) database and identified 3 pairs of monozygotic twins or duplicate samples, 100 pairs of first-degree and 161 second-degree of relationships. Three standardized subsets with different levels of unrelated individuals were suggested here for future applications of the samples in most types of population-genetics studies (denoted by PASNP1716, PASNP1640 and PASNP1583 respectively) based on the relationships inferred in this study. In addition, we provided gender information for PASNP samples, which were not included in the original dataset, based on analysis of X chromosome data
URI
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DOI
10.1371/journal.pone.0029502
ISSN
1932-6203
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BME_Journal Papers
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