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Park, Tae Joo
Developmental Morphogenesis Lab
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  • Morphogenesis, chondrogenesis, ciliogenesis

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Damage-associated molecular patterns and their pathological relevance in diabetes mellitus

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dc.contributor.author Shin, Jung Jae ko
dc.contributor.author Lee, Eun Kyung ko
dc.contributor.author Park, Tae Joo ko
dc.contributor.author Kim, Wook ko
dc.date.available 2015-09-04T05:40:43Z -
dc.date.created 2015-09-04 ko
dc.date.issued 2015-11 ko
dc.identifier.citation AGEING RESEARCH REVIEWS, v.24, pp.66 - 76 ko
dc.identifier.issn 1568-1637 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/16654 -
dc.description.abstract Diabetes, a group of metabolic and age-related diseases, is a major global health problem, the incidence of which has increased dramatically in recent decades. Type 1 diabetes mellitus (T1DM) is a complex, T cell-mediated autoimmune disease characterized by immune cell infiltration and chronic inflammation in the islets of Langerhans. Type 2 diabetes mellitus (T2DM) is a complex metabolic disease characterized by hyperglycemia (high blood sugar) resulting from insulin resistance and beta-cell dysfunction. The involvement of inflammatory processes, such as immune cell infiltration, and chronic inflammation in the pathogenesis of diabetes is less well understood in T2DM than in T1DM. However, studies conducted in the past decade have shown a strong link between inflammation and metabolic dysfunction. They have also shown that chronic inflammation plays a key role in the pathogenesis of both T1DM and T2DM. Two immunological factors commonly contribute to the pathogenesis of diabetes: the activation of inflammasomes and the release of proinflammatory cytokines in response to damage-associated molecular patterns (DAMPs). Inflammasomes are intracellular multiprotein molecular platforms. DAMPs act as endogenous danger signals. Here, we review current research on the function(s) of inflammasomes and DAMPs and discuss their pathological relevance and therapeutic implications in diabetes. ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.publisher ELSEVIER IRELAND LTD ko
dc.title Damage-associated molecular patterns and their pathological relevance in diabetes mellitus ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-84947045864 ko
dc.identifier.wosid 000366768600007 ko
dc.type.rims ART ko
dc.description.wostc 0 *
dc.description.scopustc 0 *
dc.date.tcdate 2016-01-13 *
dc.date.scptcdate 2015-11-04 *
dc.date.scptcdate 2015-11-04 *
dc.identifier.doi 10.1016/j.arr.2015.06.004 ko
dc.identifier.url http://www.sciencedirect.com/science/article/pii/S1568163715300015 ko
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