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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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ELEVATED CONTENT OF PHOSPHOLIPASE C-GAMMA-1 IN COLORECTAL-CANCER TISSUES

Cited 77 times inthomson ciCited 74 times inthomson ci
Title
ELEVATED CONTENT OF PHOSPHOLIPASE C-GAMMA-1 IN COLORECTAL-CANCER TISSUES
Author
Noh, Dong-YoungLee, Young HanKim, Sung SookKim, Yong IlRyu, Sung-HoSuh, Pann-GhillPark, Jae-Gahb
Keywords
colorectal carcinoma; immunohistochemistry; phospholipase C-γ1 expression; radioimmunoassay; signal transduction; Western blotting
Issue Date
1994-01
Publisher
WILEY-BLACKWELL
Citation
CANCER, v.73, no.1, pp.36 - 41
Abstract
Background. Phospholipase C isozymes (PLC) play a role in ligand-mediated signal transduction for cellular activity, such as proliferation and differentiation. However, the biologic significance of their molecules in carcinogenesis or tumor progression is yet to be determined. Methods. Using PLC isozyme-specific antibodies, the relative content of PLC in human colorectal carcinomas and in normal colonic mucosa was examined. Results. Immunoreactive analysis revealed considerably higher levels of PLC-gamma 1 protein in 15 of 17 colorectal carcinomas and little difference in PLC-beta 1 or PLC-delta 1 content compared with normal colorectal tissues. By radioimmunoassay and Western blotting, PLC-gamma 1 showed threefold to fourfold more expression in carcinomas than that in normal tissues. Conclusion. Although factors that might influence the level of PLC-gamma 1 expression in colorectal carcinomas still remain obscure, the fact that most colorectal carcinomas display elevated levels of PLC-gamma 1 expression implies that PLC-gamma 1 may play an important role in proliferation of colorectal carcinoma cells
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DOI
10.1002/1097-0142(19940101)73:1<36::AID-CNCR2820730108>3.0.CO;2-5
ISSN
0008-543X
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BME_Journal Papers
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