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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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DOWN-REGULATION OF PHOSPHOLIPASE C-GAMMA-1 DURING THE DIFFERENTIATION OF U937 CELLS

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Title
DOWN-REGULATION OF PHOSPHOLIPASE C-GAMMA-1 DURING THE DIFFERENTIATION OF U937 CELLS
Author
Lee, Young HanLee, He JinLee, Seung-JaeMin, Do SikBaek, Suk HwanKim, Yong SikRyu, Sung HoSuh, Pann-Ghill
Issue Date
1995-01
Publisher
ELSEVIER SCIENCE BV
Citation
FEBS LETTERS, v.358, no.2, pp.105 - 108
Abstract
Phospholipase C (PLC)-gamma 1 and -gamma 2 play a pivotal role in signal transduction for cell proliferation and differentiation. The enzyme activity and protein level of PLC-gamma 1 were markedly decreased in the human histiocytic leukemia U937 cell line during the differentiation process,which is induced by phorbol 12-myristate 13-acetate (PMA) but those of PLC-gamma 2 were not altered. Northern blot analysis showed that the levels of PLC-gamma 1 and -gamma 2 transcripts were not changed. These results suggest that the expression of PLC-gamma 1 during the PMA-induced differentiation may be down-regulated by post-transcriptional processing
URI
https://scholarworks.unist.ac.kr/handle/201301/16533
URL
http://www.sciencedirect.com/science/article/pii/001457939401404O#
DOI
10.1016/0014-5793(94)01404-O
ISSN
0014-5793
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BIO_Journal Papers
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