DOWN-REGULATION OF PHOSPHOLIPASE C-GAMMA-1 DURING THE DIFFERENTIATION OF U937 CELLS
Cited 13 times inCited 12 times in
- DOWN-REGULATION OF PHOSPHOLIPASE C-GAMMA-1 DURING THE DIFFERENTIATION OF U937 CELLS
- Lee, Young Han; Lee, He Jin; Lee, Seung-Jae; Min, Do Sik; Baek, Suk Hwan; Kim, Yong Sik; Ryu, Sung Ho; Suh, Pann-Ghill
- Issue Date
- ELSEVIER SCIENCE BV
- FEBS LETTERS, v.358, no.2, pp.105 - 108
- Phospholipase C (PLC)-gamma 1 and -gamma 2 play a pivotal role in signal transduction for cell proliferation and differentiation. The enzyme activity and protein level of PLC-gamma 1 were markedly decreased in the human histiocytic leukemia U937 cell line during the differentiation process,which is induced by phorbol 12-myristate 13-acetate (PMA) but those of PLC-gamma 2 were not altered. Northern blot analysis showed that the levels of PLC-gamma 1 and -gamma 2 transcripts were not changed. These results suggest that the expression of PLC-gamma 1 during the PMA-induced differentiation may be down-regulated by post-transcriptional processing
- Appears in Collections:
- BIO_Journal Papers
- Files in This Item:
- There are no files associated with this item.
can give you direct access to the published full text of this article. (UNISTARs only)
Show full item record
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.