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- Suh, Pann-Ghill
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DOWN-REGULATION OF PHOSPHOLIPASE C-GAMMA-1 DURING THE DIFFERENTIATION OF U937 CELLS
- Author(s)
- Lee, Young Han, Lee, He Jin, Lee, Seung-Jae, Min, Do Sik, Baek, Suk Hwan, Kim, Yong Sik, Ryu, Sung Ho, Suh, Pann-Ghill
- Issued Date
- 1995-01
- Citation
- FEBS LETTERS, v.358, no.2, pp.105 - 108
- Abstract
- Phospholipase C (PLC)-gamma 1 and -gamma 2 play a pivotal role in signal transduction for cell proliferation and differentiation. The enzyme activity and protein level of PLC-gamma 1 were markedly decreased in the human histiocytic leukemia U937 cell line during the differentiation process,which is induced by phorbol 12-myristate 13-acetate (PMA) but those of PLC-gamma 2 were not altered. Northern blot analysis showed that the levels of PLC-gamma 1 and -gamma 2 transcripts were not changed. These results suggest that the expression of PLC-gamma 1 during the PMA-induced differentiation may be down-regulated by post-transcriptional processing
- Publisher
- ELSEVIER SCIENCE BV
- ISSN
- 0014-5793
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