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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Cloning and characterization of 5 '-upstream region of human phospholipase C-beta 2 gene

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Title
Cloning and characterization of 5 '-upstream region of human phospholipase C-beta 2 gene
Author
Yun, ESLee, SJKim, MJRyu, SHSuh, Pann-Ghill
Issue Date
2001-06
Publisher
KOREAN SOC MED BIOCHEMISTRY MOLECULAR BIOLOGY
Citation
EXPERIMENTAL AND MOLECULAR MEDICINE, v.33, no.2, pp.76 - 82
Abstract
5 ' -upstream region of the phospholipase C-beta2 gene, 810 bp, was cloned and characterized. S1 nuclease mapping and primer extension analyses revealed that a single transcriptional start site locates at 284 nucleotides upstream from the beginning of translation. The 5 ' -upstream region lacks both TATA motif and typical initiator sequence, but retains CC-rich segment. Two putative regulatory regions, a negative region (-636/-588) and a positive region (-98/-13) were identified in the upstream region of PLC-beta2 gene. We suggest that the transcription of PLC-beta2 may be regulated by binding of regulatory proteins to the negative and/or positive regulatory regions located in the upstream of the gene
URI
https://scholarworks.unist.ac.kr/handle/201301/16524
URL
http://www.nature.com/emm/journal/v33/n2/abs/emm200114a.html
DOI
10.1038/emm.2001.14
ISSN
1226-3613
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