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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Inhibition of PDGF-induced phosphoinositide-turnover by glucopiericidin A

Cited 4 times inthomson ciCited 4 times inthomson ci
Title
Inhibition of PDGF-induced phosphoinositide-turnover by glucopiericidin A
Author
Ahn, SCKim, BYPark, CSLee, HSSuh, PGRyu, SHRho, HMRhee, JSMheen, TIAhn, JS
Keywords
EGF;  Glucopiericidin A;  PDGF;  Phosphoinositide-turnover;  Phospholipase Cγ1
Issue Date
1995-09
Publisher
Academic Press
Citation
BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL, v.37, no.1, pp.125 - 132
Abstract
In the search for a substance which would specifically block a particular step in the signal transduction cascade, we identified glucopiericidin A produced by Streptomyces sp, as an inhibitor of phosphoinositide (PI)-turnover in phospholipase-C gamma 1 (PLC-gamma 1) overexpressing NM 3T3 fibroblasts (NIH 3T3 gamma 1). Glucopiericidin A inhibited the formation of inositol phosphate (IPt) in platelet-derived growth factor (PDGF)-stimulated NIH 3T3 gamma 1 cells with an IC50 of 5.0 mu M, In vitro enzyme assay showed the compound had no inhibitory effect on PLC-gamma 1 even at 100 mu M concentration. Glucopiericidin A reduced PDGF-induced tyrosine phosphorylations of proteins, including PDGF receptor and PLC-gamma 1, in the cells. In contrast, glucopiericidin A showed only a slight inhibitory effect on epidermal growth factor (EGF)- (EGF)-induced IPt production and protein tyrosine phosphorylations in A431 cells. These results suggest that glucopiericidin A inhibits PDGF-induced activation of PLC-gamma 1 by reducing the tyrosine kinase activity of the PDGF receptor and it more potently inhibits PI-turnover induced by PDGF than by EGF
URI
https://scholarworks.unist.ac.kr/handle/201301/16494
ISSN
1039-9712
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