BROWSE

Related Researcher

Author's Photo

Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

ITEM VIEW & DOWNLOAD

Localization of two forms of phospholipase C-beta 1, a and b, in C6Bu-1 cells

Cited 61 times inthomson ciCited 32 times inthomson ci
Title
Localization of two forms of phospholipase C-beta 1, a and b, in C6Bu-1 cells
Author
Bahk, Young YilSong, HebokBaek, Suk HwanPark, Byung YuKim, HyunRyu, Sung HoSuh, PG
Keywords
C6Bu-1 cell; Immunocytochemistry; Nuclear localization; Phospholipase C-β1
Issue Date
1998-01
Publisher
Elsevier BV
Citation
BIOCHIMICA ET BIOPHYSICA ACTA - LIPIDS AND LIPID METABOLISM, v.1389, no.1, pp.76 - 80
Abstract
Phospholipase C-beta 1 (PLC-beta 1), one of the PLC-beta isozymes, exists as two immunologically distinguishable polypeptides of 150 (PLC-beta 1a) and 140 kDa (PLC-beta 1b) which are encoded in two distinct transcripts and generated by alternative splicing of a single gene, In this study, the subcellular localization of the two phospholipases C-beta 1 proteins was examined in rat CGBu-1 glioma cells using immunological techniques, Immunoblot analysis revealed that the two forms of PLC-beta 1 were detectible in both cytosolic and nuclear fractions, PLC-beta 1a appeared to be located preferentially in the cytosol, whereas PLC-beta 1b was found predominantly in the nuclei of C6Bu-1 cells, Immunocytochemical experiments confirmed the differential localization of the two PLC-beta 1 species in C6Bu-1 cells. These results suggest that the two PLC-beta 1 proteins may have different physiological roles in the cell. (C) 1998 Elsevier Science B.V
URI
Go to Link
DOI
10.1016/S0005-2760(97)00128-8
ISSN
0005-2760
Appears in Collections:
BME_Journal Papers
Files in This Item:
1-s2.0-S0005276097001288-main.pdf Download

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show full item record

qrcode

  • mendeley

    citeulike

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

MENU