File Download
There are no files associated with this item.
SFX Link
- Find it @ UNIST can give you direct access to the published full text of this article. (UNISTARs only)
- Suh, Pann-Ghill
Views & Downloads
Detailed Information
Cited time in 
Cited time in 
Cited time in
Metadata Downloads
Localization of two forms of phospholipase C-beta 1, a and b, in C6Bu-1 cells
- Author(s)
- Bahk, Young Yil, Song, Hebok, Baek, Suk Hwan, Park, Byung Yu, Kim, Hyun, Ryu, Sung Ho, Suh, PG
- Issued Date
- 1998-01
- Citation
- BIOCHIMICA ET BIOPHYSICA ACTA - LIPIDS AND LIPID METABOLISM, v.1389, no.1, pp.76 - 80
- Abstract
- Phospholipase C-beta 1 (PLC-beta 1), one of the PLC-beta isozymes, exists as two immunologically distinguishable polypeptides of 150 (PLC-beta 1a) and 140 kDa (PLC-beta 1b) which are encoded in two distinct transcripts and generated by alternative splicing of a single gene, In this study, the subcellular localization of the two phospholipases C-beta 1 proteins was examined in rat CGBu-1 glioma cells using immunological techniques, Immunoblot analysis revealed that the two forms of PLC-beta 1 were detectible in both cytosolic and nuclear fractions, PLC-beta 1a appeared to be located preferentially in the cytosol, whereas PLC-beta 1b was found predominantly in the nuclei of C6Bu-1 cells, Immunocytochemical experiments confirmed the differential localization of the two PLC-beta 1 species in C6Bu-1 cells. These results suggest that the two PLC-beta 1 proteins may have different physiological roles in the cell. (C) 1998 Elsevier Science B.V
- Publisher
- Elsevier BV
- ISSN
- 0005-2760
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.