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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Expression of phospholipase C-gamma 1 and its transcriptional regulators in breast cancer tissues

Cited 15 times inthomson ciCited 15 times inthomson ci
Title
Expression of phospholipase C-gamma 1 and its transcriptional regulators in breast cancer tissues
Author
Noh, DYKang, HSKim, YCYoun, YKOh, SKChoe, KJPark, IARyu, SHSuh, Pann-Ghill
Issue Date
1998-07
Publisher
INT INST ANTICANCER RESEARCH
Citation
ANTICANCER RESEARCH, v.18, no.4A, pp.2643 - 2648
Abstract
Background: PLC-gamma 1 is activated through direct interaction with growth factor receptor tyrosine kinase but little is known about the mechanisms controlling PLC-gamma 1 expression and its biological significance. Materials and methods: Using immunoblotting, we evaluated PLC-gamma 1 protein overexpression in twenty breast cancer tissues. The expression of binding protein to GES1, GES2 and GES3, located in transcriptional regulator (GPE1) was found by electrophoretic mobility shift assay (EMSA). We also determined whether there was any correlation between prognostic factors (numbers of metastatic axillary nodes, histologic grade, c-erbB2, p53, and E-cadherin) and the overexpression of PLC-gamma 1 protein. Result: On immunoblotting, 17 of 20 breast cancer tissues showed overexpression of PLC-gamma 1, a result of which was corresponded to that of immunohistochemistry. The binding proteins to GES1, GES2 and GES3 were overexpressed only when PLC-gamma 1 protein overexpression was apparent. Positive expression of E-cadherin only was significantly associated with PLC-gamma 1 protein overexpression (x = 0.607, p=0.045). Conclusion: GPE1 binding proteins might be the transcriptional regulator in PLC-gamma 1 overexpression and the relationship between expression of PLC-gamma 1 and E-cadherin would require further elucidation
URI
https://scholarworks.unist.ac.kr/handle/201301/16487
ISSN
0250-7005
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BIO_Journal Papers
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