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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Inhibition of trifluoperazine-induced DNA fragmentation by cyclic AMP mediated signaling

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Title
Inhibition of trifluoperazine-induced DNA fragmentation by cyclic AMP mediated signaling
Author
Kang, Ung GuKim, Myung JongSuh, Pann-GhillRyu, Sung HoPark, Joo-BaeKim, Jung-HyeKim, Yong SikLee, Young Han
Issue Date
1999-12
Publisher
KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
Citation
MOLECULES AND CELLS, v.9, no.6, pp.596 - 602
Abstract
Trifluoperazine (TFP), a phenothiazine antipsychotic agent with calmodulin antagonist property, induces DNA fragmentation in a dose- and time-dependent manner in PC12 cells, Various agents affecting calcium mediated intracellular signal transduction such as calcium chelators, calcium ionopores, inhibitors of phospholipase C, and activators/inhibitors of protein kinase C did not block TFP-induced DNA fragmentation, Some of these agents themselves induced DNA fragmentation in the conditions under which they were examined, However, cholera toxin (selective Gs activator), forskolin (adenylate cyclase activator) or dibutyryl cyclic AMP (cyclic AMP analogue) inhibited TFP-induced DNA fragmentation in a dose-dependent manner. These results suggest that it is not the calcium but the Gs and adenylate cyclase pathways that play an important role in TFP-induced DNA fragmentation in PC12 cells
URI
https://scholarworks.unist.ac.kr/handle/201301/16484
URL
http://www.molcells.org/journal/view.html?year=1999&volume=9&number=6&spage=596
ISSN
1016-8478
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BIO_Journal Papers
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