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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Immunological characterization of 130 kDa phospholipase C-beta 4 isozyme in rat cerebellar Purkinje cells

Cited 7 times inthomson ciCited 6 times inthomson ci
Title
Immunological characterization of 130 kDa phospholipase C-beta 4 isozyme in rat cerebellar Purkinje cells
Author
Min, Do SikKim, Myung JongJeong, Hyun KyungLee, Young HanKim, HyunShin, Hee-SupRyu, Sung HoSuh, Pann-Ghill
Issue Date
2000-09
Publisher
ELSEVIER IRELAND LTD
Citation
NEUROSCIENCE LETTERS, v.292, no.1, pp.9 - 12
Abstract
We have developed a monoclonal antibody, beta 4-22-9 that recognizes an epitope on pleckstrin homology (PH) domain (1-136 amino acids) located at the amino terminus of rat 130 kDa phospholipase C-beta 4 (PLC-beta 4). Tissue distribution of 130 kDa PLC-beta 4 was determined with this monoclonal antibody. One hundred and thirty kiloDalton PLC-beta 4 was exclusively expressed in the nervous tissues including cerebellum and cerebrum, especially at very high levels in cerebellum. The expression of 130 kDa PLC-beta 4 in cerebellum was gradually increased from 5 days after birth to adulthood. in the adult cerebellum, especially high level of 130 kDa PLC-beta 4 was localized on the periphery of Purkinje cells in the patch-like pattern. These data implies that 130 kDa PLC-beta 4 may a role in cerebellar Purkinje cells. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved
URI
https://scholarworks.unist.ac.kr/handle/201301/16479
URL
http://www.sciencedirect.com/science/article/pii/S0304394000014191
DOI
10.1016/S0304-3940(00)01419-1
ISSN
0304-3940
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