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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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STUDIES OF INOSITOL PHOSPHOLIPID SPECIFIC PHOSPHOLIPASE-C

Cited 912 times inthomson ciCited 466 times inthomson ci
Title
STUDIES OF INOSITOL PHOSPHOLIPID SPECIFIC PHOSPHOLIPASE-C
Author
Rhee, Sue GooSuh, Pann-GhillRyu, Sung-HoLee, Sang Yeol
Keywords
Amino Acid Sequence; Animal; Cell Membrane; Comparative Study; Cytosol; Isoenzymes; Phosphatidylinositols; Phosphoric Diester Hydrolases; Phosphorylation; Second Messenger Systems; Terminology
Issue Date
1989-05
Publisher
AMER ASSOC ADVANCEMENT SCIENCE
Citation
SCIENCE, v.244, no.4904, pp.546 - 550
Abstract
Inositol phospholipid - specific phospholipase C is the enzyme that generates phosphoinositide-derived messenger molecules. Mammalian cells contain at least five immunologically distinct phospholipase C enzymes that appear to be separate gene products. Complete amino acid sequences of four of these isozymes have been established. The overall sequence similarity is surprisingly low for enzymes catalyzing the same chemical reaction: three of them show limited amino acid sequence similarity to each other in two narrow regions, and the fourth enzyme is completely different. The diversity in primary structure together with different regional and cellular expression of the isozymes suggests that each isozyme has a defined function in processing the physiological response of different cell types to a variety of external stimuli and that each is regulated differently.
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DOI
10.1126/science.2541501
ISSN
0036-8075
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BME_Journal Papers
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