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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Plasma cell granuloma in cyclosporine-induced gingival overgrowth - A report of two cases with immurlohistochemical positivity of interleukin-6 and phospholipase C-gamma 1

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Title
Plasma cell granuloma in cyclosporine-induced gingival overgrowth - A report of two cases with immurlohistochemical positivity of interleukin-6 and phospholipase C-gamma 1
Author
Kim, Sung SookEom, DaewoonHuh, JooryungSung, Lel-YongChoi, InpyoRyu, Sung HoSuh, Pann-GhillChung, Sung-Min
Issue Date
2002-10
Publisher
KOREAN ACAD MEDICAL SCIENCES
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE, v.17, no.5, pp.704 - 707
Abstract
We report two cases of gingival plasma cell granuloma in a 34-yr-old and 40-yrold two male renal transplant recipients with cyclosporine A (CsA)-induced gingival overgrowth (GO). Histologically, these lesions were composed of mature plasma cells, showing polyclonality for both lambda and kappa light chains and fibrovascular connective tissue stroma. In addition to the fact that CsA-induced plasma cell granuloma is rare, the salient features of our cases were the secretion of interleukin-6 and overexpression of phospholipase C-gamma1 of the tumor cells, which may explain the mechanisms of CsA-induced GO
URI
https://scholarworks.unist.ac.kr/handle/201301/16444
URL
http://synapse.koreamed.org/DOIx.php?id=10.3346/jkms.2002.17.5.704
DOI
10.3346/jkms.2002.17.5.704
ISSN
1011-8934
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BIO_Journal Papers
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