BROWSE

Related Researcher

Author's Photo

Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

ITEM VIEW & DOWNLOAD

Thimerosal stimulates focal adhesion kinase and cytoskeletal changes by redox modulation

Cited 13 times inthomson ciCited 14 times inthomson ci
Title
Thimerosal stimulates focal adhesion kinase and cytoskeletal changes by redox modulation
Author
Kim, EuikyungKim, Jung HwanKim, Hyeon SooRyu, Sung HoSuh, Pann-Ghill
Keywords
Cytoskeletal change; Focal adhesion kinase; Reactive oxygen species; Thimerosal; Tyrosine phosphorylation
Issue Date
2002-12
Publisher
ELSEVIER SCIENCE BV
Citation
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, v.1593, no.1, pp.9 - 15
Abstract
Thimerosal is one of the most widely used preservatives and has been reported to cause chemically mediated side effects. However, the mechanism of the side effects is not clearly understood yet. In the present study, we showed that HeLa S cells treated by thimerosal generated reactive oxygen species (ROS). Thimerosal-generated ROS stimulated the tyrosine phosphorylation of focal adhesion kinase (FAK) and also induced cytoskeletal changes. Pretreatment with intracellular calcium chelator, BAPTA did not block the thimerosal-mediated FAK tyrosine phosphorylation. On the other hand, either FAK inhibitor, tyrphostin or ROS scavenger, N-acetyl-L-cysteine (NAC) suppressed the tyrosine phosphorylation and cytoskeletal changes. These results suggest that thimerosal seems to induce FAK tyrosine phosphorylation and cytoskeletal changes by ROS generation but not by intracellular calcium mobilization. We think the present finding can be an important clue to understanding the mechanism of thimerosal-mediated side effects, such as contact dermatitis, and allergy. (C) 2002 Elsevier Science B.V. All rights reserved
URI
Go to Link
DOI
10.1016/S0167-4889(02)00275-6
ISSN
0167-4889
Appears in Collections:
BME_Journal Papers
Files in This Item:
1-s2.0-S0167488902002756-main.pdf Download

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show full item record

qrcode

  • mendeley

    citeulike

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

MENU