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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Syntheses of sphingosine-1-phosphate stereoisomers and analogues and their interaction with EDG receptors

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Title
Syntheses of sphingosine-1-phosphate stereoisomers and analogues and their interaction with EDG receptors
Author
Lim, Hyun-SukOh, Yong-SeokSuh, Pann-GhillChung, Sung-Kee
Keywords
endothelial differentiation gene receptor; G protein coupled receptor; ligand; sphingosine 1 phosphate; unclassified drug; cell surface receptor; drug derivative; dyes, reagents, indicators, markers and buffers; G protein coupled receptor; immediate early protein; lysophospholipid; lysophospholipid receptor; sphingosine; sphingosine 1 phosphate; sphingosine 1-phosphate
Issue Date
2003-01
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.13, no.2, pp.237 - 240
Abstract
Sphingosine-1-phosphate (S1P) is considered to be an important regulator of diverse biological processes acting as a natural ligand to EDG receptors. As a preliminary study to develop potent and selective agonist and antagonist for EDG receptors, we report synthesis of S1P stereoisomers and analogues and their binding affinities to EDG-1, -3, and -5. (C) 2002 Elsevier Science Ltd. All rights reserved
URI
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DOI
10.1016/S0960-894X(02)00893-4
ISSN
0960-894X
Appears in Collections:
BME_Journal Papers
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