Secretin induces neurite outgrowth of PC12 through cAMP-mitogen-activated protein kinase pathway
Cited 19 times inCited 17 times in
- Secretin induces neurite outgrowth of PC12 through cAMP-mitogen-activated protein kinase pathway
- Kim, Hyeon Soo; Yumkham, Sanatombi; Kim, Sun-Hee; Yea, Kyungmoo; Shin, You Chan; Ryu, Sung Ho; Suh, Pann-Ghill
- Issue Date
- KOREAN SOC MED BIOCHEMISTRY MOLECULAR BIOLOGY
- EXPERIMENTAL AND MOLECULAR MEDICINE, v.38, no.1, pp.85 - 93
- The gastrointestinal functions of secretin have been fairly well established. However, its function and mode of action within the nervous system remain largely unclear. To gain insight into this area, we have attempted to determine the effects of secretin on neuronal differentiation. Here, we report that secretin induces the generation of neurite outgrowth in pheochromocytoma PC12 cells. The expressions of Tau and beta-tubulin, neuronal differentiation markers, are increased upon secretin stimulation. In addition, secretin induces sustained mitogen-activated protein kinase (MAPK) activation and also stimulates the cAMP secretion. Moreover, the neurite outgrowth elicited by secretin is suppressed to a marked degree in the presence of either PD98059, a specific MAPK/ERK kinase (MEK) inhibitor, or H89, a specific protein kinase A (PKA) inhibitor. Taken together, these observations demonstrate that secretin induces neurite outgrowth of PC12 cells through cAMP-MAPK pathway, and provide a novel insight into the manner in which secretin participates in neuritogenesis
- Appears in Collections:
- BIO_Journal Papers
- Files in This Item:
- There are no files associated with this item.
can give you direct access to the published full text of this article. (UNISTARs only)
Show full item record
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.