BROWSE

Related Researcher

Author's Photo

Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

ITEM VIEW & DOWNLOAD

Secretin induces neurite outgrowth of PC12 through cAMP-mitogen-activated protein kinase pathway

Cited 19 times inthomson ciCited 17 times inthomson ci
Title
Secretin induces neurite outgrowth of PC12 through cAMP-mitogen-activated protein kinase pathway
Author
Kim, Hyeon SooYumkham, SanatombiKim, Sun-HeeYea, KyungmooShin, You ChanRyu, Sung HoSuh, Pann-Ghill
Keywords
Mitogen-activated protein kinases; Neurites; Pheochromocytoma; Secretin; Tau proteins
Issue Date
2006-02
Publisher
KOREAN SOC MED BIOCHEMISTRY MOLECULAR BIOLOGY
Citation
EXPERIMENTAL AND MOLECULAR MEDICINE, v.38, no.1, pp.85 - 93
Abstract
The gastrointestinal functions of secretin have been fairly well established. However, its function and mode of action within the nervous system remain largely unclear. To gain insight into this area, we have attempted to determine the effects of secretin on neuronal differentiation. Here, we report that secretin induces the generation of neurite outgrowth in pheochromocytoma PC12 cells. The expressions of Tau and beta-tubulin, neuronal differentiation markers, are increased upon secretin stimulation. In addition, secretin induces sustained mitogen-activated protein kinase (MAPK) activation and also stimulates the cAMP secretion. Moreover, the neurite outgrowth elicited by secretin is suppressed to a marked degree in the presence of either PD98059, a specific MAPK/ERK kinase (MEK) inhibitor, or H89, a specific protein kinase A (PKA) inhibitor. Taken together, these observations demonstrate that secretin induces neurite outgrowth of PC12 cells through cAMP-MAPK pathway, and provide a novel insight into the manner in which secretin participates in neuritogenesis
URI
Go to Link
DOI
10.1038/emm.2006.10
ISSN
1226-3613
Appears in Collections:
BME_Journal Papers
Files in This Item:
emm200610a.pdf Download

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show full item record

qrcode

  • mendeley

    citeulike

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

MENU