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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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TYROSINE PHOSPHORYLATION OF PLC-GAMMA(1) INDUCED BY ELECTROCONVULSIVE SHOCK IN RAT HIPPOCAMPUS

Cited 11 times inthomson ciCited 7 times inthomson ci
Title
TYROSINE PHOSPHORYLATION OF PLC-GAMMA(1) INDUCED BY ELECTROCONVULSIVE SHOCK IN RAT HIPPOCAMPUS
Author
Lee, Young HanRyu, Sung HoSuh, Pann-GhillPark, Joo-BaeAhn, Yong-MinKim, Yong Sik
Keywords
animal experiment; animal tissue; article; electric shock; hippocampus; nonhuman; phosphoinositide metabolism; priority journal; protein phosphorylation; rat; signal transduction
Issue Date
1993-07
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Citation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.194, no.2, pp.665 - 670
Abstract
ECS has been shown to increase PIP2 breakdown in rat brain, which suggested the possible activation of PLC-signal transduction system by ECS. When we examined the PLC-γ1 immunoprecipitated from rat hippocampal tissues after ECS, we found a rapid increase in phosphotyrosine of PLC-γ1, which reached peak at 10 minutes after ECS and returned to basal level after 2 hours. There was no change in the amount of PLC-γ1 proteins during that period. The tyrosine phosphorylation induced by ECS didn′t affect the enzyme activity when assayed in vitro. These results suggested that ECS may activate PLC-γ1 by phosphorylation on tyrosine residue, but without changing enzyme activity itself. © 1993 Academic Press. All rights reserved.
URI
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DOI
10.1006/bbrc.1993.1873
ISSN
0006-291X
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BME_Journal Papers
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