TYROSINE PHOSPHORYLATION OF PLC-GAMMA(1) INDUCED BY ELECTROCONVULSIVE SHOCK IN RAT HIPPOCAMPUS
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- TYROSINE PHOSPHORYLATION OF PLC-GAMMA(1) INDUCED BY ELECTROCONVULSIVE SHOCK IN RAT HIPPOCAMPUS
- Lee, Young Han; Ryu, Sung Ho; Suh, Pann-Ghill; Park, Joo-Bae; Ahn, Yong-Min; Kim, Yong Sik
- animal experiment; animal tissue; article; electric shock; hippocampus; nonhuman; phosphoinositide metabolism; priority journal; protein phosphorylation; rat; signal transduction
- Issue Date
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.194, no.2, pp.665 - 670
- ECS has been shown to increase PIP2 breakdown in rat brain, which suggested the possible activation of PLC-signal transduction system by ECS. When we examined the PLC-γ1 immunoprecipitated from rat hippocampal tissues after ECS, we found a rapid increase in phosphotyrosine of PLC-γ1, which reached peak at 10 minutes after ECS and returned to basal level after 2 hours. There was no change in the amount of PLC-γ1 proteins during that period. The tyrosine phosphorylation induced by ECS didn′t affect the enzyme activity when assayed in vitro. These results suggested that ECS may activate PLC-γ1 by phosphorylation on tyrosine residue, but without changing enzyme activity itself. © 1993 Academic Press. All rights reserved.
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