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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Transformation of rat fibroblasts by phospholipase C-gamma 1 overexpression is accompanied by tyrosine dephosphorylation of paxillin

Cited 12 times inthomson ciCited 13 times inthomson ci
Title
Transformation of rat fibroblasts by phospholipase C-gamma 1 overexpression is accompanied by tyrosine dephosphorylation of paxillin
Author
Chang, Jong-SooIwashita, ShintaroLee, Young HanKim, Myung JongRyu, Sung HoSuh, Pann-Ghill
Issue Date
1999-10
Publisher
ELSEVIER SCIENCE BV
Citation
FEBS LETTERS, v.460, no.1, pp.161 - 165
Abstract
We previously have shown that the overexpression of phospholipase C-gamma l (PLC-gamma l) in rat 3Y1 fibroblasts results in malignant transformation (Chang, J.-S., Noh, D.Y., Park, I.A., Kim, M.J., Song, H., Ryu, S.H. and Suh, P.-G. (1997) Cancer Res. 57, 5465-5468), The transformed cells, which initially are in an elongated and flat form after seeding in plastic dishes, become rounded during continued culture, We found that tyrosine dephosphorylation of paxillin accompanies this morphological change of the transformed cells and that PLC-gamma l co-immunoprecipitates together with paxillin and vice versa, but not after the cells have become round, Transformed cells growing on fibronectin-pre-coated dishes regain their flat morphology and this is accompanied by paxillin tyrosine phosphorylation, Furthermore, immunoprecipitation analysis showed that paxillin forms a heteromeric complex with PLC-gamma l in cells grown on fibronectin, These results suggest that a complex formation between paxillin and PLC-gamma l may play a role in cell-substrate adhesion. (C) 1999 Federation of European Biochemical Societies
URI
https://scholarworks.unist.ac.kr/handle/201301/16434
URL
http://www.sciencedirect.com/science/article/pii/S0014579399013381
DOI
10.1016/S0014-5793(99)01338-1
ISSN
0014-5793
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BIO_Journal Papers
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