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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Spiraeoside inhibits mast cells activation and IgE-mediated allergic responses by suppressing phospholipase C-gamma-mediated signaling

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Title
Spiraeoside inhibits mast cells activation and IgE-mediated allergic responses by suppressing phospholipase C-gamma-mediated signaling
Author
Kim, Jung KukSeo, Young-KyoPark, SehoonPark, Soo-AhLim, SeyoungLee, SusieKwon, OhmanSeo, Jeong KonChoi, Ung-KyuRyu, Sung HoSuh, Pann-Ghill
Issue Date
2015-06
Publisher
CANADIAN SCIENCE PUBLISHING
Citation
BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE, v.93, no.3, pp.227 - 235
Abstract
Mast cells are responsible for IgE-mediated allergic responses through the secretion of various inflammatory cytokines and mediators. Therefore, the pharmacological regulation of mast cell activation is an important goal in the development of novel anti-allergic drugs. In this study, we found that spiraeoside (SP) inhibits mast cell activation and allergic responses in vivo. SP dose-dependently inhibited the degranulation induced by IgE-antigen (Ag) stimulation in RBL-2H3 mast cells without cytotoxic effects. At the molecular level, SP reduced the Ag-induced phosphorylation and subsequent activation of phospholipase C-gamma 2 (PLC-gamma 2). Moreover, SP inhibited the phosphorylation of spleen tyrosine kinase (Syk), linker for activation of T cells (LAT), and downstream MAPKs, such as ERK1/2, p38, and JNK, eventually attenuating expression of TNF-alpha and IL-4. Finally, we found that SP significantly inhibited IgE-mediated passive cutaneous anaphylaxis (PCA) in mice. Taken together, our results strongly suggest that SP suppresses IgE-mediated mast cell activation and allergic responses by inhibiting Lyn-induced PLC-gamma 2/MAPK signaling in mast cells
URI
https://scholarworks.unist.ac.kr/handle/201301/16409
URL
http://www.nrcresearchpress.com/doi/10.1139/bcb-2014-0055#.VdWyobLtlBc
DOI
10.1139/bcb-2014-0055
ISSN
0829-8211
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UCRF_Journal Papers
BME_Journal Papers
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