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Kee, Jung-Min
Bioorganic and Chembio Lab
Research Interests
  • Chemical biology, organic synthesis, peptide chemistry, synthetic protein chemistry

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Practical synthesis of prostratin, DPP, and their analogs, adjuvant leads against latent HIV

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Title
Practical synthesis of prostratin, DPP, and their analogs, adjuvant leads against latent HIV
Other Titles
Practical synthesis of prostratin, DPP, and their analogs, adjuvant lead s against latent HIV
Author
Wender, Paul A.Kee, Jung-MinWarrington, Jeffrey M.
Issue Date
2008-05
Publisher
AMER ASSOC ADVANCEMENT SCIENCE
Citation
SCIENCE, v.320, no.5876, pp.649 - 652
Abstract
Although antiretroviral therapies have been effective in decreasing active viral loads in AIDS patients, the persistence of latent viral reservoirs prevents eradication of the virus. Prostratin and DPP ( 12- deoxyphorbol- 13- phenylacetate) activate the latent virus and thus represent promising adjuvants for antiviral therapy. Their limited supply and the challenges of accessing related structures have, however, impeded therapeutic development and the search for clinically superior analogs. Here we report a practical synthesis of prostratin and DPP starting from phorbol or crotophorbolone, agents readily available from renewable sources, including a biodiesel candidate. This synthesis reliably supplies gram quantities of the therapeutically promising natural products, hitherto available only in low and variable amounts from natural sources, and opens access to a variety of new analogs.
URI
https://scholarworks.unist.ac.kr/handle/201301/13344
URL
http://www.sciencemag.org/content/320/5876/649
DOI
10.1126/science.1154690
ISSN
0036-8075
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CHM_Journal Papers
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