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Kwon, Taejoon
TaejoonLab
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  • Systems biology, computational biology, functional genomics

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Role of Pseudomonas aeruginosa Peptidoglycan-Associated Outer Membrane Proteins in Vesicle Formation

Cited 17 times inthomson ciCited 18 times inthomson ci
Title
Role of Pseudomonas aeruginosa Peptidoglycan-Associated Outer Membrane Proteins in Vesicle Formation
Other Titles
Role of Pseudomonas aeruginosa Peptidoglycan-Associated Outer Membrane Proteins in Vesicle Formation
Author
Wessel, Aimee K.Liew, JeanKwon, TaejoonMarcotte, Edward M.Whiteley, Marvin
Keywords
TANDEM MASS-SPECTRA; GRAM-NEGATIVE BACTERIA; GROWING ESCHERICHIA-COLI; NEISSERIA-GONORRHOEAE; QUINOLONE SIGNAL; SEPTUM FORMATION; DATABASE SEARCH; LIPOPROTEIN PAL; CELL-ENVELOPE; MUTANTS
Issue Date
2013-01
Publisher
AMER SOC MICROBIOLOGY
Citation
JOURNAL OF BACTERIOLOGY, v.195, no.2, pp.213 - 219
Abstract
Gram-negative bacteria produce outer membrane vesicles (OMVs) that package and deliver proteins, small molecules, and DNA to prokaryotic and eukaryotic cells. The molecular details of OMV biogenesis have not been fully elucidated, but peptidoglycan-associated outer membrane proteins that tether the outer membrane to the underlying peptidoglycan have been shown to be critical for OMV formation in multiple Enterobacteriaceae. In this study, we demonstrate that the peptidoglycan-associated outer membrane proteins OprF and OprI, but not OprL, impact production of OMVs by the opportunistic pathogen Pseudomonas aeruginosa. Interestingly, OprF does not appear to be important for tethering the outer membrane to peptidoglycan but instead impacts OMV formation through modulation of the levels of the Pseudomonas quinolone signal (PQS), a quorum signal previously shown by our laboratory to be critical for OMV formation. Thus, the mechanism by which OprF impacts OMV formation is distinct from that for other peptidoglycan-associated outer membrane proteins, including OprI
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DOI
10.1128/JB.01253-12
ISSN
0021-9193
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BME_Journal Papers
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