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Kwon, Taejoon
TaejoonLab
Research Interests
  • Systems biology, computational biology, functional genomics

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Coordinated genomic control of ciliogenesis and cell movement by RFX2

Cited 17 times inthomson ciCited 16 times inthomson ci
Title
Coordinated genomic control of ciliogenesis and cell movement by RFX2
Other Titles
Coordinated genomic control of ciliogenesis and cell movement by RFX2
Author
Chung, Mei-IKwon, TaejoonTu, FanBrooks, Eric R.Gupta, RakhiMeyer, MatthewBaker, Julie C.Marcotte, Edward M.Wallingford, John B.
Keywords
PRIMARY CILIARY DYSKINESIA; HUMAN AIRWAY EPITHELIUM; GENE-EXPRESSION DATA; INTRAFLAGELLAR TRANSPORT; BASAL-CELLS; INTERACTION NETWORKS; STEM-CELLS; PROTEIN; XENOPUS; POLARITY
Issue Date
2014-01
Publisher
ELIFE SCIENCES PUBLICATIONS LTD, SHERATON HOUSE, CASTLE PARK, CAMBRIDGE, CB3 0AX, ENGLAND
Citation
ELIFE, v.2014, no.3, pp.e01439 -
Abstract
The mechanisms linking systems-level programs of gene expression to discrete cell biological processes in vivo remain poorly understood. In this study, we have defined such a program for multi-ciliated epithelial cells (MCCs), a cell type critical for proper development and homeostasis of the airway, brain and reproductive tracts. Starting from genomic analysis of the cilia-associated transcription factor Rfx2, we used bioinformatics and in vivo cell biological approaches to gain insights into the molecular basis of cilia assembly and function. Moreover, we discovered a previously unrecognized role for an Rfx factor in cell movement, finding that Rfx2 cell-autonomously controls apical surface expansion in nascent MCCs. Thus, Rfx2 coordinates multiple, distinct gene expression programs in MCCs, regulating genes that control cell movement, ciliogenesis, and cilia function. As such, the work serves as a paradigm for understanding genomic control of cell biological processes that span from early cell morphogenetic events to terminally differentiated cellular functions
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DOI
10.7554/eLife.01439
ISSN
2050-084X
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